Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | - |
dc.contributor.author | 이정현 | - |
dc.date.accessioned | 2016-08-28T12:08:18Z | - |
dc.date.available | 2016-08-28T12:08:18Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.other | OAK-5810 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220212 | - |
dc.description.abstract | Although phosphatidylinositol 4,5-bisphosphate (PIP2) regulates syndecan-4 function, the potential influence of syndecan-4 on PIP2 remains unknown. GFP containing PIP2-binding-PH domain of phospholipase Cδ (GFP-PHδ) was used to monitor PIP2. Syndecan-4 overexpression in COS-7 cells enhanced membrane translocation of GFP-PHδ, while the opposite was observed when syndecan-4 was knocked-down. PIP2 levels were higher in total phospholipids extracted from rat embryo fibroblasts expressing syndecan-4. Syndecan-4-induced membrane targeting of GFP-PHδ was further enhanced by phosphoinositide-3-kinase inhibitor, but not by phospholipase C (PLC) inhibitor. Besides, both ionomycin and epidermal growth factor caused dissociation of GFP-PHδ from plasma membrane, an effect that was significantly delayed by syndecan-4 over-expression. Collectively, these data suggest that syndecan-4 promotes plasma membrane retention of PIP2 by negatively regulating PLC-dependent PIP2 degradation. © 2009 Federation of European Biochemical Societies. | - |
dc.language | English | - |
dc.title | Syndecan-4 promotes the retention of phosphatidylinositol 4,5-bisphosphate in the plasma membrane | - |
dc.type | Article | - |
dc.relation.issue | 14 | - |
dc.relation.volume | 583 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2395 | - |
dc.relation.lastpage | 2400 | - |
dc.relation.journaltitle | FEBS Letters | - |
dc.identifier.doi | 10.1016/j.febslet.2009.06.039 | - |
dc.identifier.wosid | WOS:000268563000014 | - |
dc.identifier.scopusid | 2-s2.0-67650101214 | - |
dc.author.google | Kwon S. | - |
dc.author.google | Son H. | - |
dc.author.google | Choi Y. | - |
dc.author.google | Lee J.-h. | - |
dc.author.google | Choi S. | - |
dc.author.google | Lim Y. | - |
dc.author.google | Han I.-O. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20190901081003 | - |