Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이공주 | - |
dc.contributor.author | 김희정 | - |
dc.contributor.author | 김현정 | - |
dc.date.accessioned | 2016-08-28T12:08:08Z | - |
dc.date.available | 2016-08-28T12:08:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | OAK-5309 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220116 | - |
dc.description.abstract | Ubiquitin C-terminal hydrolase-L1 (UCH-L1) catalyses the hydrolysis of ubiquitin ester and amide mainly in neuronal cells. Recently it was proposed as a marker with a potential role in carcinogenesis. However, the molecular mechanism underlying the biological function of UCH-L1 in tumor cells is poorly understood. We found that UCH-L1 is highly expressed in non-small lung cancer cell line H157, having high invasive potential, and that the expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway. Suppressing UCH-L1 expression by RNAi significantly suppressed the invasion in vitro and in vivo, and the activation of Akt and downstream mitogen activated protein kinases c-Jun N-terminal kinases and p38, but not ERK. In Akt-negative mutants, overexpression of UCH-L1 does not affect the invasion and migration capability of H157 cells. These results suggest that UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. © 2009 Macmillan Publishers Limited All rights reserved. | - |
dc.language | English | - |
dc.title | Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 117 | - |
dc.relation.lastpage | 127 | - |
dc.relation.journaltitle | Oncogene | - |
dc.identifier.doi | 10.1038/onc.2008.364 | - |
dc.identifier.wosid | WOS:000262294100012 | - |
dc.identifier.scopusid | 2-s2.0-58149350275 | - |
dc.author.google | Kim H.J. | - |
dc.author.google | Kim Y.M. | - |
dc.author.google | Lim S. | - |
dc.author.google | Nam Y.K. | - |
dc.author.google | Jeong J. | - |
dc.author.google | Kim H.-J. | - |
dc.author.google | Lee K.-J. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.contributor.scopusid | 김희정(57206210649) | - |
dc.date.modifydate | 20230208115507 | - |