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dc.contributor.author이공주-
dc.contributor.author김희정-
dc.contributor.author김현정-
dc.date.accessioned2016-08-28T12:08:08Z-
dc.date.available2016-08-28T12:08:08Z-
dc.date.issued2009-
dc.identifier.issn0950-9232-
dc.identifier.otherOAK-5309-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220116-
dc.description.abstractUbiquitin C-terminal hydrolase-L1 (UCH-L1) catalyses the hydrolysis of ubiquitin ester and amide mainly in neuronal cells. Recently it was proposed as a marker with a potential role in carcinogenesis. However, the molecular mechanism underlying the biological function of UCH-L1 in tumor cells is poorly understood. We found that UCH-L1 is highly expressed in non-small lung cancer cell line H157, having high invasive potential, and that the expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway. Suppressing UCH-L1 expression by RNAi significantly suppressed the invasion in vitro and in vivo, and the activation of Akt and downstream mitogen activated protein kinases c-Jun N-terminal kinases and p38, but not ERK. In Akt-negative mutants, overexpression of UCH-L1 does not affect the invasion and migration capability of H157 cells. These results suggest that UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. © 2009 Macmillan Publishers Limited All rights reserved.-
dc.languageEnglish-
dc.titleUbiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume28-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage117-
dc.relation.lastpage127-
dc.relation.journaltitleOncogene-
dc.identifier.doi10.1038/onc.2008.364-
dc.identifier.wosidWOS:000262294100012-
dc.identifier.scopusid2-s2.0-58149350275-
dc.author.googleKim H.J.-
dc.author.googleKim Y.M.-
dc.author.googleLim S.-
dc.author.googleNam Y.K.-
dc.author.googleJeong J.-
dc.author.googleKim H.-J.-
dc.author.googleLee K.-J.-
dc.contributor.scopusid이공주(7501497635)-
dc.contributor.scopusid김희정(56984353900;56984399000;56984349600)-
dc.date.modifydate20210301081004-
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약학대학 > 약학과 > Journal papers
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