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dc.contributor.author권영주-
dc.date.accessioned2016-08-28T12:08:06Z-
dc.date.available2016-08-28T12:08:06Z-
dc.date.issued2008-
dc.identifier.issn0253-2964-
dc.identifier.otherOAK-5201-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220095-
dc.description.abstractA series of new derivatives on the ring A of luotonin A were prepared by Friedländer condensation of 6,7,8,10-tetrahydropyrrolo[2,1-b]quinazoline-6, 10-dione and suitably substituted 2-aminobenzaldehydes and 2-aminoacetophenones. Their inhibitory activities on topoisomerases and cytotoxicities against selected human cancer cell lines were evaluated. Among the compounds tested, 8-fluoroluotonin A showed similar inhibitory activity on topoisomerase I comparable to camptothecin while luotonin A and 9-hydroxyluotonin A showed 1.37 and 0.94 times stronger inhibitory activity, respectively, on topoisomerase II compared to etoposide. Some derivatives of luotonin A showed moderate cytotoxicity. The possible relationship between the inhibitory activity on Topo II and the cytotoxicity of luotonin A and its analogues, thus, cannot be ruled out.-
dc.languageEnglish-
dc.titleSynthesis and Biological Properties of Luotonin a Derivatives-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume29-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage1988-
dc.relation.lastpage1992-
dc.relation.journaltitleBulletin of the Korean Chemical Society-
dc.identifier.wosidWOS:000260810500024-
dc.identifier.scopusid2-s2.0-55249090178-
dc.author.googleRahman A.F.M.M.-
dc.author.googleDong H.K.-
dc.author.googleJing L.L.-
dc.author.googleLee E.-S.-
dc.author.googleNa Y.-
dc.author.googleJun K.-Y.-
dc.author.googleKwon Y.-
dc.author.googleJahng Y.-
dc.contributor.scopusid권영주(12446435600;57281846700)-
dc.date.modifydate20220119154509-
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약학대학 > 약학과 > Journal papers
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