Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.contributor.author | 심인경 | - |
dc.date.accessioned | 2016-08-28T12:08:06Z | - |
dc.date.available | 2016-08-28T12:08:06Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-5188 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220090 | - |
dc.description.abstract | Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been identified as a potential source of therapy for human cancers. However, PPARγ ligands have a limitation for breast cancer therapy, since estrogen receptor α (ERα) negatively interferes with PPARγ signaling in breast cancer cells. Here we show that ERα inhihits PPARγ transactivity and ERα-mediated inhibition of PPARγ transactivity is blocked by tamoxifen, an estrogen receptor blocker. The activation of ERα with 17-β-estradiol blocked PPRE transactivity induced by troglitazone, a PPARγ ligand, indicating the resistance of ERα-positive breast cancer cells to troglitazone. Indeed, troglitazone inhibited the growth of ERα-negative MDA-MB-231 cells more than that of ERα-positive MCF-7 cells. Combination of troglitazone with tamoxifen led to a marked increase in growth inhibition of ERα-positive MCF-7 cells compared to either agent alone. Our data indicates that troglitazone enhances the growth inhibitory activity of tamoxifen in ERα-positive MCF-7 cells. © 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 377 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 242 | - |
dc.relation.lastpage | 247 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.09.111 | - |
dc.identifier.wosid | WOS:000260738500047 | - |
dc.identifier.scopusid | 2-s2.0-54449088704 | - |
dc.author.google | Yu H.-N. | - |
dc.author.google | Noh E.-M. | - |
dc.author.google | Lee Y.-R. | - |
dc.author.google | Roh S.-G. | - |
dc.author.google | Song E.-K. | - |
dc.author.google | Han M.-K. | - |
dc.author.google | Lee Y.-C. | - |
dc.author.google | Shim I.K. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Jung S.H. | - |
dc.author.google | Kim J.-S. | - |
dc.author.google | Youn H.J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.contributor.scopusid | 심인경(9638245900) | - |
dc.date.modifydate | 20230530112823 | - |