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약학대학
약학과
Journal papers
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Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells
Title
Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells
Authors
Yu H.-N.
;
Noh E.-M.
;
Lee Y.-R.
;
Roh S.-G.
;
Song E.-K.
;
Han M.-K.
;
Lee Y.-C.
;
Shim I.K.
;
Lee S.J.
;
Jung S.H.
;
Kim J.-S.
;
Youn H.J.
Ewha Authors
이승진
;
심인경
SCOPUS Author ID
이승진
; 심인경
Issue Date
2008
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291X
Citation
Biochemical and Biophysical Research Communications vol. 377, no. 1, pp. 242 - 247
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been identified as a potential source of therapy for human cancers. However, PPARγ ligands have a limitation for breast cancer therapy, since estrogen receptor α (ERα) negatively interferes with PPARγ signaling in breast cancer cells. Here we show that ERα inhihits PPARγ transactivity and ERα-mediated inhibition of PPARγ transactivity is blocked by tamoxifen, an estrogen receptor blocker. The activation of ERα with 17-β-estradiol blocked PPRE transactivity induced by troglitazone, a PPARγ ligand, indicating the resistance of ERα-positive breast cancer cells to troglitazone. Indeed, troglitazone inhibited the growth of ERα-negative MDA-MB-231 cells more than that of ERα-positive MCF-7 cells. Combination of troglitazone with tamoxifen led to a marked increase in growth inhibition of ERα-positive MCF-7 cells compared to either agent alone. Our data indicates that troglitazone enhances the growth inhibitory activity of tamoxifen in ERα-positive MCF-7 cells. © 2008 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2008.09.111
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