View : 717 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author정낙신-
dc.contributor.author이상국-
dc.contributor.author최원준-
dc.date.accessioned2016-08-28T12:08:04Z-
dc.date.available2016-08-28T12:08:04Z-
dc.date.issued2008-
dc.identifier.issn0022-2623-
dc.identifier.otherOAK-5134-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220078-
dc.description.abstractNovel D- and L-4′-thioadenosine derivatives lacking the 4′-hydroxymethyl moiety were synthesized, starting from D-mannose and D-gulonic γ-lactone, respectively, as potent and selective species-independent A3 adenosine receptor (AR) antagonists. Among the novel 4′-truncated 2-H nucleosides tested, a N6-(3- chlorobenzyl) derivative 7c was the most potent at the human A3 AR (Ki = 1.5 nM), but a N6-(3-bromobenzyl) derivative 7d showed the optimal species-independent binding affinity. © 2008 American Chemical Society.-
dc.languageEnglish-
dc.titleStructure-activity relationships of truncated D- and L-4′- thioadenosine derivatives as species-independent A3 adenosine receptor antagonists-
dc.typeArticle-
dc.relation.issue20-
dc.relation.volume51-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage6609-
dc.relation.lastpage6613-
dc.relation.journaltitleJournal of Medicinal Chemistry-
dc.identifier.doi10.1021/jm8008647-
dc.identifier.wosidWOS:000260102700038-
dc.identifier.scopusid2-s2.0-54549084548-
dc.author.googleLak S.J.-
dc.author.googlePal S.-
dc.author.googleSeung A.C.-
dc.author.googleWon J.C.-
dc.author.googleJacobson K.A.-
dc.author.googleGao Z.-G.-
dc.author.googleKlutz A.M.-
dc.author.googleHou X.-
dc.author.googleHea O.K.-
dc.author.googleHyuk W.L.-
dc.author.googleSang K.L.-
dc.author.googleTosh D.K.-
dc.author.googleHyung R.M.-
dc.contributor.scopusid정낙신(16028528200)-
dc.contributor.scopusid이상국(36067620500)-
dc.contributor.scopusid최원준(55732412300;57211762651)-
dc.date.modifydate20230627112239-
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE