Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-28T12:08:00Z | - |
dc.date.available | 2016-08-28T12:08:00Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0918-6158 | * |
dc.identifier.other | OAK-4968 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220039 | - |
dc.description.abstract | We previously reported that poncirin, a flavanone glycoside isolated from the EtOAc extract of the dried immature fruits of Poncirus trifoliata, is an anti-inflammatory compound that inhibits PGE 2 and IL-6 production. The present work was undertaken to investigate the molecular actions of poncirin in RAW 264.7 macrophage cell line. Poncirin reduced lipopolysaccharide (LPS)-induced protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the mRNA expressions of iNOS, COX-2, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a concentration- dependent manner, as determined by Western blotting and RT-PCR, respectively. Furthermore, poncirin inhibited the LPS-induced DNA binding activity of nuclear factor-κB (NF-κB). Moreover, this effect was accompanied by a parallel reduction in IκB-α degradation and phosphorylation that in by nuclear translocations of p50 and p65 NF-βB subunits. Taken together, our data indicate that anti-inflammatory properties of poncirin might be the result from the inhibition iNOS, COX-2, TNF-α and IL-6 expression via the down-regulation of NF-κB binding activity. © 2007 Pharmaceutical Society of Japan. | * |
dc.language | English | * |
dc.title | Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cells | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2345 | * |
dc.relation.lastpage | 2351 | * |
dc.relation.journaltitle | Biological and Pharmaceutical Bulletin | * |
dc.identifier.doi | 10.1248/bpb.30.2345 | * |
dc.identifier.wosid | WOS:000257874600021 | * |
dc.identifier.scopusid | 2-s2.0-36849072564 | * |
dc.author.google | Kim J.-B. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Park E.-Y. | * |
dc.author.google | Kim J.-Y. | * |
dc.author.google | Cho W. | * |
dc.author.google | Lee J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee K.-T. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |