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dc.contributor.author정화순-
dc.contributor.author허정원-
dc.date.accessioned2016-08-28T12:08:55Z-
dc.date.available2016-08-28T12:08:55Z-
dc.date.issued2007-
dc.identifier.issn1598-6535-
dc.identifier.otherOAK-4737-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/219987-
dc.description.abstractBACKGROUND: HLA-DR negativity is known to be useful for distinguishing acute promyelocytic leukemia (APL) from other subtypes of AML, but non-APL cases without HLA-DR antigen expression have been reported. The purpose of this study was to evaluate and compare the characteristics of APL, HLA-DR negative non-APL, and HLA-DR positive non-APL cases. METHODS: A total of 114 cases of AML admitted at Ewha Womans University, Mokdong Hospital between March 1997 and June 2006 were included in this study. A diagnosis of AML was made based on the results of morphology, cytochemistry, immunophenotype, cytogenetics, and/or fluorescence in situ hybridization. RESULTS: Among the 114 AML patients, HLA-DR antigen was not expressed in 39 (34%), including 24 non-APL (62%) and 15 APL patients (38%). The HLA-DR negative non-APL group showed higher leukocyte counts and positive rate of CD19 expression than did APL group (P<0.05). The remaining laboratory findings were not statistically different between the HLA-DR negative non-APL and APL groups. CD34 expression was more frequent in the HLA-DR positive non-APL group than in the HLA-DR negative non-APL group and APL group. Of the 24 patients with HLA-DR negative non-APL, 7 patients had disseminated intravascular coagulation and 2 patients showed morphologic features similar to those of APL. CONCLUSIONS: CD19 expression and leukocyte count may be helpful for differentiating HLA-DR negative non-APL from APL. However, the final diagnosis and classification should be confirmed by cytogenetic or molecular studies.-
dc.languageEnglish-
dc.titleCharacteristics of acute myeloid leukemia without HLA-DR expression.-
dc.typeArticle-
dc.relation.issue5-
dc.relation.volume27-
dc.relation.indexSCOPUS-
dc.relation.startpage313-
dc.relation.lastpage317-
dc.relation.journaltitleThe Korean journal of laboratory medicine-
dc.identifier.doi10.3343/kjlm.2007.27.5.313-
dc.identifier.wosidWOS:000254915300002-
dc.identifier.scopusid2-s2.0-56149111117-
dc.author.googleMoon H.-
dc.author.googleLee S.-
dc.author.googleHuh J.-
dc.author.googleChung W.S.-
dc.contributor.scopusid정화순(7401983201)-
dc.contributor.scopusid허정원(7102258576)-
dc.date.modifydate20180608120342-
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의과대학 > 의학과 > Journal papers
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