Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정화순 | - |
dc.contributor.author | 허정원 | - |
dc.date.accessioned | 2016-08-28T12:08:55Z | - |
dc.date.available | 2016-08-28T12:08:55Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1598-6535 | - |
dc.identifier.other | OAK-4737 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219987 | - |
dc.description.abstract | BACKGROUND: HLA-DR negativity is known to be useful for distinguishing acute promyelocytic leukemia (APL) from other subtypes of AML, but non-APL cases without HLA-DR antigen expression have been reported. The purpose of this study was to evaluate and compare the characteristics of APL, HLA-DR negative non-APL, and HLA-DR positive non-APL cases. METHODS: A total of 114 cases of AML admitted at Ewha Womans University, Mokdong Hospital between March 1997 and June 2006 were included in this study. A diagnosis of AML was made based on the results of morphology, cytochemistry, immunophenotype, cytogenetics, and/or fluorescence in situ hybridization. RESULTS: Among the 114 AML patients, HLA-DR antigen was not expressed in 39 (34%), including 24 non-APL (62%) and 15 APL patients (38%). The HLA-DR negative non-APL group showed higher leukocyte counts and positive rate of CD19 expression than did APL group (P<0.05). The remaining laboratory findings were not statistically different between the HLA-DR negative non-APL and APL groups. CD34 expression was more frequent in the HLA-DR positive non-APL group than in the HLA-DR negative non-APL group and APL group. Of the 24 patients with HLA-DR negative non-APL, 7 patients had disseminated intravascular coagulation and 2 patients showed morphologic features similar to those of APL. CONCLUSIONS: CD19 expression and leukocyte count may be helpful for differentiating HLA-DR negative non-APL from APL. However, the final diagnosis and classification should be confirmed by cytogenetic or molecular studies. | - |
dc.language | English | - |
dc.title | Characteristics of acute myeloid leukemia without HLA-DR expression. | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 27 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 313 | - |
dc.relation.lastpage | 317 | - |
dc.relation.journaltitle | The Korean journal of laboratory medicine | - |
dc.identifier.doi | 10.3343/kjlm.2007.27.5.313 | - |
dc.identifier.wosid | WOS:000254915300002 | - |
dc.identifier.scopusid | 2-s2.0-56149111117 | - |
dc.author.google | Moon H. | - |
dc.author.google | Lee S. | - |
dc.author.google | Huh J. | - |
dc.author.google | Chung W.S. | - |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | - |
dc.contributor.scopusid | 허정원(7102258576) | - |
dc.date.modifydate | 20230616163225 | - |