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dc.contributor.author사홍기-
dc.date.accessioned2016-08-28T12:08:53Z-
dc.date.available2016-08-28T12:08:53Z-
dc.date.issued2008-
dc.identifier.issn0378-5173-
dc.identifier.otherOAK-4639-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/219963-
dc.description.abstractThe chemical stability of a proton-pump inhibitor, rabeprazole sodium, was evaluated in simulated intestinal fluid (pH 6.8) containing various 'Generally Recognized As Safe (GRAS)'-listed excipients, including Brij® 58, Poloxamer 188, Cremophor RH40, Gelucire 44/14 and PEG 6000. After incubation at 37 and 60 °C, the amounts of rabeprazole and its degradation product, thioether-rabeprazole, were quantitated by HPLC analysis. The main degradation product was separated and characterized by LC/MS. The degradation of rabeprazole followed first-order kinetics. In the absence of any excipients, the rate constants (k) obtained at 37 and 60 °C were 0.75 and 2.78 h-1, respectively. In contrast, the addition of excipients improved its stability. Among several excipients tested in this study, Brij® 58 displayed the greatest stabilizing effect. For instance, at 37 and 60 °C, Brij® 58 reduced the k values to 0.22 and 0.53 h-1, respectively. The stabilizing mechanisms of these hydrophilic polymeric excipients with optimal HLB values could be partially explained in terms of their solubilizing efficiency and micellar formation for thioether-rabeprazole. In conclusion, rabeprazole formulations that contain suitable excipients would improve its stability in the intestinal tract, thereby maximizing bioavailability. © 2007.-
dc.languageEnglish-
dc.titleEffect of pharmaceutical excipients on aqueous stability of rabeprazole sodium-
dc.typeArticle-
dc.relation.issue41276-
dc.relation.volume350-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage197-
dc.relation.lastpage204-
dc.relation.journaltitleInternational Journal of Pharmaceutics-
dc.identifier.doi10.1016/j.ijpharm.2007.08.035-
dc.identifier.wosidWOS:000253504100024-
dc.identifier.scopusid2-s2.0-38349165563-
dc.author.googleRen S.-
dc.author.googlePark M.-J.-
dc.author.googleSah H.-
dc.author.googleLee B.-J.-
dc.contributor.scopusid사홍기(56127728100)-
dc.date.modifydate20190901081003-
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약학대학 > 약학과 > Journal papers
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