Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 사홍기 | - |
dc.date.accessioned | 2016-08-28T12:08:53Z | - |
dc.date.available | 2016-08-28T12:08:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.other | OAK-4639 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219963 | - |
dc.description.abstract | The chemical stability of a proton-pump inhibitor, rabeprazole sodium, was evaluated in simulated intestinal fluid (pH 6.8) containing various 'Generally Recognized As Safe (GRAS)'-listed excipients, including Brij® 58, Poloxamer 188, Cremophor RH40, Gelucire 44/14 and PEG 6000. After incubation at 37 and 60 °C, the amounts of rabeprazole and its degradation product, thioether-rabeprazole, were quantitated by HPLC analysis. The main degradation product was separated and characterized by LC/MS. The degradation of rabeprazole followed first-order kinetics. In the absence of any excipients, the rate constants (k) obtained at 37 and 60 °C were 0.75 and 2.78 h-1, respectively. In contrast, the addition of excipients improved its stability. Among several excipients tested in this study, Brij® 58 displayed the greatest stabilizing effect. For instance, at 37 and 60 °C, Brij® 58 reduced the k values to 0.22 and 0.53 h-1, respectively. The stabilizing mechanisms of these hydrophilic polymeric excipients with optimal HLB values could be partially explained in terms of their solubilizing efficiency and micellar formation for thioether-rabeprazole. In conclusion, rabeprazole formulations that contain suitable excipients would improve its stability in the intestinal tract, thereby maximizing bioavailability. © 2007. | - |
dc.language | English | - |
dc.title | Effect of pharmaceutical excipients on aqueous stability of rabeprazole sodium | - |
dc.type | Article | - |
dc.relation.issue | 41276 | - |
dc.relation.volume | 350 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 197 | - |
dc.relation.lastpage | 204 | - |
dc.relation.journaltitle | International Journal of Pharmaceutics | - |
dc.identifier.doi | 10.1016/j.ijpharm.2007.08.035 | - |
dc.identifier.wosid | WOS:000253504100024 | - |
dc.identifier.scopusid | 2-s2.0-38349165563 | - |
dc.author.google | Ren S. | - |
dc.author.google | Park M.-J. | - |
dc.author.google | Sah H. | - |
dc.author.google | Lee B.-J. | - |
dc.contributor.scopusid | 사홍기(56127728100) | - |
dc.date.modifydate | 20190901081003 | - |