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dc.contributor.author오세관-
dc.contributor.author정재철-
dc.date.accessioned2016-08-28T12:08:52Z-
dc.date.available2016-08-28T12:08:52Z-
dc.date.issued2008-
dc.identifier.issn0932-0776-
dc.identifier.otherOAK-4594-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/219955-
dc.description.abstractA convenient synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1- phenethylpropylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl esters 17 and 18 as new cysteine protease inhibitors is described. The synthetic key strategies involve the diazocarbonyl insertion reaction of N-Boc-L-homophenylalanine (1) by diazomethane, acetylation of the bromoketone 2 with sodium acetate, and condensation of acids 12, 14 with (3S)-3-amino-2-oxo-5-phenyl-pentyl acetate monohydrochloride (4) in good yield. © 2008 Verlag der Zeitschrift für Naturforschung.-
dc.languageEnglish-
dc.titleA simple synthesis of 4-substituted 2-(3-hydroxy-2-oxo-1-phenethyl- propylcarbamoyl)pyrrolidine-1-carboxylic acid benzyl esters as novel cysteine protease inhibitors-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume63-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage210-
dc.relation.lastpage216-
dc.relation.journaltitleZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences-
dc.identifier.wosidWOS:000253003200015-
dc.identifier.scopusid2-s2.0-39449118654-
dc.author.googleOh S.-
dc.author.googleJung J.-C.-
dc.contributor.scopusid오세관(7404103757)-
dc.contributor.scopusid정재철(7402897187)-
dc.date.modifydate20220112112005-
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의과대학 > 의학과 > Journal papers
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