Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.contributor.author | 심인경 | - |
dc.date.accessioned | 2016-08-28T12:08:52Z | - |
dc.date.available | 2016-08-28T12:08:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-4560 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219951 | - |
dc.description.abstract | NAD is available in the extracellular environment and elicits immune modulation such as T cell apoptosis by being used as the substrate of cell surface ADP-ribosyl transferase. However, it is unclear whether extracellular NAD affects function of macrophages expressing cell surface ADP-ribosyl transferase. Here we show that extracellular NAD enhances Fcγ receptor (FcγR)-mediated phagocytosis in J774A.1 macrophages via the conversion into cyclic ADP-ribose (cADPR), a potent calcium mobilizer, by CD38, an ADP-ribosyl cyclase. Extracellular NAD increased the phagocytosis of IgG-coated sheep red blood cells (IgG-SRBC) in J774A.1 macrophages, which was completely abolished by pretreatment of 8-bromo-cADPR, an antagonist of cADPR, or CD38 knockdown. Extracellular NAD increased basal intracellular Ca2+ concentration, which also was abolished by pretreatment of 8-bromo-cADPR or CD38 knockdown. Moreover, the chelation of intracellular calcium abolished NAD-induced enhancement of phagocytosis of IgG-SRBC. Our results suggest that extracellular NAD act as a regulator for FcγR-mediated phagocytosis in macrophages. © 2007 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Extracellular NAD is a regulator for FcγR-mediated phagocytosis in murine macrophages | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 367 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 156 | - |
dc.relation.lastpage | 161 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.12.131 | - |
dc.identifier.wosid | WOS:000252619700025 | - |
dc.identifier.scopusid | 2-s2.0-38049033871 | - |
dc.author.google | Song E.-K. | - |
dc.author.google | Lee Y.-R. | - |
dc.author.google | Yu H.-N. | - |
dc.author.google | Kim U.-H. | - |
dc.author.google | Rah S.-Y. | - |
dc.author.google | Park K.-H. | - |
dc.author.google | Shim I.-K. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Park Y.-M. | - |
dc.author.google | Chung W.-G. | - |
dc.author.google | Kim J.-S. | - |
dc.author.google | Han M.-K. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.contributor.scopusid | 심인경(9638245900) | - |
dc.date.modifydate | 20230530112823 | - |