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dc.contributor.author정낙신-
dc.date.accessioned2016-08-28T12:08:50Z-
dc.date.available2016-08-28T12:08:50Z-
dc.date.issued2007-
dc.identifier.issn1525-7770-
dc.identifier.otherOAK-4503-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/219933-
dc.description.abstractNovel l-bicyclocarba-d4T (1), an enantiomer of d-N-MCd4T has been enantiopurely synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, Grignard reaction, RCM reaction, and Mitsunobu reaction as key steps. l-N-MCd4T (1) was found to be very potent anti-HIV-1 (EC50 = 6.76 μg/mL) agent with no cytotoxicity. Copyright © Taylor & Francis Group, LLC.-
dc.languageEnglish-
dc.titleAsymmetric synthesis and biological activity of l-bicyclocarba-d4T-
dc.typeArticle-
dc.relation.issue41559-
dc.relation.volume26-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1653-
dc.relation.lastpage1657-
dc.relation.journaltitleNucleosides, Nucleotides and Nucleic Acids-
dc.identifier.doi10.1080/15257770701615599-
dc.identifier.wosidWOS:000251875500093-
dc.identifier.scopusid2-s2.0-36949034506-
dc.author.googleMoon H.R.-
dc.author.googlePark A.-Y.-
dc.author.googleKim K.R.-
dc.author.googleChun M.W.-
dc.author.googleJeong L.S.-
dc.contributor.scopusid정낙신(16028528200)-
dc.date.modifydate20211210153610-
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약학대학 > 약학과 > Journal papers
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