DSpace at EWHA: Asymmetric synthesis and biological activity of l-bicyclocarba-d4T

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DC Field	Value	Language
dc.contributor.author	정낙신	-
dc.date.accessioned	2016-08-28T12:08:50Z	-
dc.date.available	2016-08-28T12:08:50Z	-
dc.date.issued	2007	-
dc.identifier.issn	1525-7770	-
dc.identifier.other	OAK-4503	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/219933	-
dc.description.abstract	Novel l-bicyclocarba-d4T (1), an enantiomer of d-N-MCd4T has been enantiopurely synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, Grignard reaction, RCM reaction, and Mitsunobu reaction as key steps. l-N-MCd4T (1) was found to be very potent anti-HIV-1 (EC50 = 6.76 μg/mL) agent with no cytotoxicity. Copyright © Taylor & Francis Group, LLC.	-
dc.language	English	-
dc.title	Asymmetric synthesis and biological activity of l-bicyclocarba-d4T	-
dc.type	Article	-
dc.relation.issue	41559	-
dc.relation.volume	26	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	1653	-
dc.relation.lastpage	1657	-
dc.relation.journaltitle	Nucleosides, Nucleotides and Nucleic Acids	-
dc.identifier.doi	10.1080/15257770701615599	-
dc.identifier.wosid	WOS:000251875500093	-
dc.identifier.scopusid	2-s2.0-36949034506	-
dc.author.google	Moon H.R.	-
dc.author.google	Park A.-Y.	-
dc.author.google	Kim K.R.	-
dc.author.google	Chun M.W.	-
dc.author.google	Jeong L.S.	-
dc.contributor.scopusid	정낙신(16028528200)	-
dc.date.modifydate	20211210153610	-