Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오억수 | - |
dc.contributor.author | 이정현 | - |
dc.date.accessioned | 2016-08-28T12:08:49Z | - |
dc.date.available | 2016-08-28T12:08:49Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-4452 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219923 | - |
dc.description.abstract | Focal adhesion kinase (FAK) mediates signal transduction in response to multiple extracellular inputs, via tyrosine phosphorylation at specific residues. We recently reported that FAK Tyr-407 phosphorylation negatively regulates the enzymatic and biological activities of FAK, unlike phosphorylation of other tyrosine residues. In this study, we further investigated the effect of FAK Tyr-407 phosphorylation on cell transformation. We found that FAK Tyr-407 phosphorylation was lower in H-Ras transformed NIH3T3 and K-Ras transformed rat-2 fibroblasts than in the respective untransformed control cells. Consistently, FAK Tyr-407 phosphorylation was decreased in parallel with cell transformation in H-Ras-inducible NIH3T3 cells and increased during trichostatin A-induced detransformation of both K-Ras transformed rat-2 fibroblasts and H-Ras transformed NIH3T3 cells. In addition, overexpression of a phosphorylation-mimicking FAK Tyr-407 mutant inhibited morphological transformation of H-Ras-inducible NIH3T3 cells and inhibited invasion activity and anchorage-independent growth of H-Ras-transformed NIH3T3 cells. Taken together, these data strongly suggest that FAK Tyr-407 phosphorylation negatively regulates transformation of fibroblasts. © 2007 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Phosphorylation of focal adhesion kinase at Tyrosine 407 negatively regulates Ras transformation of fibroblasts | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 364 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1062 | - |
dc.relation.lastpage | 1066 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.10.134 | - |
dc.identifier.wosid | WOS:000251358500057 | - |
dc.identifier.scopusid | 2-s2.0-36048974618 | - |
dc.author.google | Jeon J. | - |
dc.author.google | Lee H. | - |
dc.author.google | Park H. | - |
dc.author.google | Lee J.-h. | - |
dc.author.google | Choi S. | - |
dc.author.google | Hwang J. | - |
dc.author.google | Han I.-O. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20190901081003 | - |