DSpace at EWHA: Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors

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DC Field	Value	Language
dc.contributor.author	이상국	*
dc.contributor.author	권영주	*
dc.date.accessioned	2016-08-28T12:08:44Z	-
dc.date.available	2016-08-28T12:08:44Z	-
dc.date.issued	2007	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-4109	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/219874	-
dc.description.abstract	An intramolecular radical cyclization reaction of 4-bromo-3-arylisoquinolines 11a-c allowed the efficient synthesis of 11-methylindenoisoquinolines 2a-c. 5-(2-Aminoethylamino)indeno[1,2-c]isoquinolin-11-one 4 was also prepared in the convenient manner. The synthesized compounds were tested in vitro for cytotoxicity and DNA-topoisomerase 1 (top 1) inhibitory activity. The dramatic enhancement of top 1 inhibitory activity of 4 was explained by a docking study using the FlexX program. © 2007 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors	*
dc.type	Article	*
dc.relation.issue	13	*
dc.relation.volume	17	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	3531	*
dc.relation.lastpage	3534	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2007.04.064	*
dc.identifier.wosid	WOS:000247864100001	*
dc.identifier.scopusid	2-s2.0-34250168713	*
dc.author.google	Cho W.-J.	*
dc.author.google	Le Q.M.	*
dc.author.google	My Van H.T.	*
dc.author.google	Youl Lee K.	*
dc.author.google	Kang B.Y.	*
dc.author.google	Lee E.-S.	*
dc.author.google	Lee S.K.	*
dc.author.google	Kwon Y.	*
dc.contributor.scopusid	이상국(36067620500)	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240123101932	*