Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.date.accessioned | 2016-08-28T12:08:41Z | - |
dc.date.available | 2016-08-28T12:08:41Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0304-3940 | * |
dc.identifier.other | OAK-3970 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219851 | - |
dc.description.abstract | Interleukin-1 receptor antagonist (IL-1ra) is a naturally occurring antagonist of IL-1α and IL-1β binding to the IL-1 receptors and alleviates various inflammatory reactions. Therefore, the upregulation of IL-1ra expression is important for preventing and/or treating inflammatory diseases including many neurodegenerative diseases. This study found that SB203580, which is generally known as a p38 MAP kinase inhibitor and an anti-inflammatory agent, increased the level of IL-1ra expression in IFN-γ-stimulated BV2 microglial cells. This effect is believed to occur through the inhibition of protein kinase B (PKB), independently of the p38 MAP kinase pathways. Further mechanistic studies using an IL-1ra promoter revealed that a composite NF-κB/PU.1 binding site plays an important role in this SB203580-mediated upregulation of IL-1ra. Considering that IFN-γ is a major stimulator of the innate and adaptive immune responses, the upregulation of anti-inflammatory IL-1ra expression by SB203580 in the IFN-γ-stimulated microglia might provide a new therapeutic modality for various inflammatory diseases of the central nervous system. © 2007 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | SB203580 enhances interleukin-1 receptor antagonist gene expression in IFN-γ-stimulated BV2 microglial cells through a composite nuclear factor-κB/PU.1 binding site | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 416 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 169 | * |
dc.relation.lastpage | 174 | * |
dc.relation.journaltitle | Neuroscience Letters | * |
dc.identifier.doi | 10.1016/j.neulet.2007.02.005 | * |
dc.identifier.wosid | WOS:000246039100013 | * |
dc.identifier.scopusid | 2-s2.0-33947280379 | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Jung S.-H. | * |
dc.author.google | Seo H. | * |
dc.author.google | Kim H.-S. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.date.modifydate | 20240215165648 | * |