Measuring H2O2 produced in response to cell surface receptor activation

Abstract

Quantitative detection of H2O2, which is increasingly recognized as an intracellular messenger, remains a challenge for cell biologists. The development of molecular probes that fluoresce upon H 2O2-mediated removal of a boronate-based protecting group, rather than upon nonspecific oxidation, demonstrates that this challenge is not insurmountable. © 2007 Nature Publishing Group.