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dc.contributor.author이상국-
dc.contributor.author서은경-
dc.contributor.author한아름-
dc.date.accessioned2016-08-28T11:08:04Z-
dc.date.available2016-08-28T11:08:04Z-
dc.date.issued2006-
dc.identifier.issn0163-3864-
dc.identifier.otherOAK-3314-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/219696-
dc.description.abstractA new prenylated chalcone, 3″,3″-dimethylpyrano[3′, 4′]2,4,2′-trihydroxychalcone (1), was isolated from the heartwood of Artocarpus communis. Two flavonoid derivatives, (-)-cycloartocarpin (9) and (-)-cudraflavone A (10), were isolated as new isomers. In addition, eight known flavonoids, isobacachalcone (2), morachalcone A (3), gemichalcones B (4) and C (5), artocarpin (6), cudraflavone C (7), licoflavone C (8), and (2S)-euchrenone a7 (11), were isolated and identified from this plant for the first time. Compounds 1-4, 6, and 11 exhibited potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC 50 values of 18.8, 6.4, 16.4, 9.3, 18.7, and 12.3, μM, respectively. The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. © 2006 American Chemical Society and American Society of Pharmacognosy.-
dc.languageEnglish-
dc.titlePrenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume69-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage719-
dc.relation.lastpage721-
dc.relation.journaltitleJournal of Natural Products-
dc.identifier.doi10.1021/np0600346-
dc.identifier.wosidWOS:000237343400046-
dc.identifier.scopusid2-s2.0-33744502095-
dc.author.googleHan A.-R.-
dc.author.googleKang Y.-J.-
dc.author.googleWindono T.-
dc.author.googleLee S.K.-
dc.author.googleSeo E.-K.-
dc.contributor.scopusid이상국(36067620500)-
dc.contributor.scopusid서은경(7005953758)-
dc.contributor.scopusid한아름(56278315000)-
dc.date.modifydate20211210153309-
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약학대학 > 약학과 > Journal papers
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