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Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism
- Title
- Arsenic trioxide inhibits cell growth in SH-SY5Y and SK-N-AS neuroblastoma cell lines by a different mechanism
- Authors
- Woo S.-Y.; Lee M.-Y.; Jung Y.-J.; Yoo E.-S.; Seoh J.-Y.; Shin H.-Y.; Ahn H.-S.; Ryu K.-H.
- Ewha Authors
- 서주영; 유경하; 유은선; 우소연
- SCOPUS Author ID
- 서주영; 유경하; 유은선; 우소연
- Issue Date
- 2006
- Journal Title
- Pediatric Hematology and Oncology
- ISSN
- 0888-0018
- Citation
- Pediatric Hematology and Oncology vol. 23, no. 3, pp. 231 - 243
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Neuroblastoma, characterized by heterogeneous cell population, is a common solid tumor in childhood and some malignant neuroblastomas are refractory to conventional chemotherapy. Recently, treatment with arsenic trioxide (As 2 O 3 ) was found effective in the treatment of acute promyelocytic leukemia as well as neuroblastoma cells by inducing apoptosis. To define the mechanism contributing to cell death in those heterogenous cell populations, the authors used two different types of neuroblastoma cells, SH-SY5Y and SK-N-AS, to compare the pathways that mediate death response to arsenic trioxide. With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity. Although caspase 3 was activated in both cell lines, the NF-?B activity and the expression of cyclin D1, cyclin E, and p27 were different. Therefore, arsenic trioxide could be an effective cytotoxic drug for the treatment of heterogeneous cellular population of neuroblastoma. Copyright © Taylor & Francis Group, LLC.
- DOI
- 10.1080/08880010500506818
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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