Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T11:08:02Z | - |
dc.date.available | 2016-08-28T11:08:02Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 1226-8372 | * |
dc.identifier.other | OAK-3197 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219675 | - |
dc.description.abstract | Telomerase activation is detected in most cancerous cells; hence, telomerase is a highly selective target for cancer therapy, which plays an important role in the apoptotic process. We have previously reported that the ginseng saponin metabolite, Compound K (20-O-D-glucopyranosyl-20(S)-protopanaxadiol, IH901), inhibits cell proliferation by inducing apoptosis and cell cycle arrest at the G1 phase. The present study investigated the regulation of telomerase activity in Compound K treated U937 cells. Compound K treatment caused a reduction in telomerase activity and down-regulated the human telomerase reverse transcriptase (hTERT) gene, resulting in the decreased expressions of its protein, and of the c-Myc and Sp1 proteins (transcription factors of hTERT). These results indicate that the anticancer activity of Compound K could be mediated by inhibition of the telomerase activity. © KSBB. | * |
dc.language | English | * |
dc.title | Inhibition of telomerase activity in U937 human monocytic leukemia cells by Compound K, a ginseng saponin metabolite | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 7 | * |
dc.relation.lastpage | 12 | * |
dc.relation.journaltitle | Biotechnology and Bioprocess Engineering | * |
dc.identifier.wosid | WOS:000235722500002 | * |
dc.identifier.scopusid | 2-s2.0-33644786182 | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Lee K.H. | * |
dc.author.google | Chae S. | * |
dc.author.google | Kim J.K. | * |
dc.author.google | Seo J.Y. | * |
dc.author.google | Ham Y.H. | * |
dc.author.google | Kim B.J. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |