DSpace at EWHA: 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

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DC Field	Value	Language
dc.contributor.author	유충규	-
dc.contributor.author	이상국	-
dc.date.accessioned	2016-08-28T11:08:40Z	-
dc.date.available	2016-08-28T11:08:40Z	-
dc.date.issued	2004	-
dc.identifier.issn	0960-894X	-
dc.identifier.other	OAK-2211	-
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/219434	-
dc.description.abstract	A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed. © 2004 Elsevier Ltd. All rights reserved.	-
dc.language	English	-
dc.title	6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents	-
dc.type	Article	-
dc.relation.issue	13	-
dc.relation.volume	14	-
dc.relation.index	SCI	-
dc.relation.index	SCIE	-
dc.relation.index	SCOPUS	-
dc.relation.startpage	3385	-
dc.relation.lastpage	3388	-
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	-
dc.identifier.doi	10.1016/j.bmcl.2004.04.094	-
dc.identifier.wosid	WOS:000221998100002	-
dc.identifier.scopusid	2-s2.0-2942598298	-
dc.author.google	Park H.J.	-
dc.author.google	Kim Y.-S.	-
dc.author.google	Kim J.S.	-
dc.author.google	Lee E.-J.	-
dc.author.google	Yi Y.-J.	-
dc.author.google	Hwang H.J.	-
dc.author.google	Suh M.-E.	-
dc.author.google	Ryu C.-K.	-
dc.author.google	Lee S.K.	-
dc.contributor.scopusid	유충규(15846918400)	-
dc.contributor.scopusid	이상국(36067620500)	-
dc.date.modifydate	20211210153309	-