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Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction
- Title
- Serum cytokine profiles in patients with Plasmodium vivax malaria: A comparison between those who presented with and without hepatic dysfunction
- Authors
- Yeom J.-S.; Park S.-H.; Ryu S.-H.; Park H.-K.; Woo S.-Y.; Ha E.-H.; Lee B.-E.; Yoo K.; Lee J.-H.; Kim K.-H.; Kim S.; Kim Y.-A.; Ahn S.-Y.; Oh S.; Park H.-J.; Min G.-S.; Seoh J.-Y.; Park J.-W.
- Ewha Authors
- 박혜경; 서주영; 하은희; 김광호; 유권; 이주호; 우소연
- SCOPUS Author ID
- 박혜경; 서주영; 하은희; 김광호; 유권; 이주호; 우소연
- Issue Date
- 2003
- Journal Title
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- ISSN
- 0035-9203
- Citation
- Transactions of the Royal Society of Tropical Medicine and Hygiene vol. 97, no. 6, pp. 687 - 691
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The aim of this study was to compare the serum cytokine profiles of Plasmodium vivax malaria patients who presented with and without hepatic dysfunction. This is a retrospective analysis of 74 consecutive cases of P. vivax malaria seen at 3 military hospitals near the Demilitarized Zone in South Korea from 1999 to 2000. All patients studied were adult active duty servicemen. On admission, the mean (± SEM) age of the patients who presented with (n = 36) and without hepatic dysfunction (n = 38) was 21.6 ± 0.24 and 22.5 ± 0.44 years, respectively (P = 0.72). On admission, there was no significant difference between the 2 patient populations in terms of mean temperature, haemoglobin level, haematocrit, total white blood cell count, platelet count, parasite index, and serum concentration of transforming growth factor-β. Plasmodium vivax malaria patients who presented with hepatic dysfunction had significantly higher mean serum concentrations of soluble Fas ligand, interleukin (IL)-l, IL-4, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ than those without hepatic dysfunction, suggesting the involvement of these cytokines in the development of hepatic dysfunction. The mean serum concentration of IL-12 was significantly lower in patients with hepatic dysfunction. The mean body temperature was not significantly different between the 2 patient populations.
- DOI
- 10.1016/S0035-9203(03)80104-9
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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