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Regulation and destabilization of HIF-1α by ARD1-mediated acetylation

Title
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
Authors
Jeong J.-W.Bae M.-K.Ahn M.-Y.Kim S.-H.Sohn T.-K.Bae M.-H.Yoo M.-A.Song E.J.Lee K.-J.Kim K.-W.
Ewha Authors
이공주
SCOPUS Author ID
이공주scopusscopus
Issue Date
2002
Journal Title
Cell
ISSN
0092-8674JCR Link
Citation
Cell vol. 111, no. 5, pp. 709 - 720
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability. Recently, prolyl hydroxylation was identified as a key regulatory event that targets the HIF-1α subunit for proteasomal degradation via the pVHL ubiquitination complex. In this report, we reveal an important function for ARD1 in mammalian cells as a protein acetyltransferase by direct binding to HIF-1α to regulate its stability. We present further evidence showing that ARD1-mediated acetylation enhances interaction of HIF-1α with pVHL and HIF-1α ubiquitination, suggesting that the acetylation of HIF-1α by ARD1 is critical to proteasomal degradation. Therefore, we have concluded that the role of ARD1 in the acetylation of HIF-1α provides a key regulatory mechanism underlying HIF-1α stability.
DOI
10.1016/S0092-8674(02)01085-1
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약학대학 > 약학과 > Journal papers
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