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Blood-brain barrier disruption following the internal carotid arterial perfusion of alkyl glycerols

Title
Blood-brain barrier disruption following the internal carotid arterial perfusion of alkyl glycerols
Authors
Lee H.J.Zhang Y.Pardridge W.M.
Ewha Authors
이화정
SCOPUS Author ID
이화정scopus
Issue Date
2002
Journal Title
Journal of Drug Targeting
ISSN
1061-186XJCR Link
Citation
Journal of Drug Targeting vol. 10, no. 6, pp. 463 - 467
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Non ionic, amphipathic molecules form vesicles and this property correlates with the disruption of membranes. In the present studies, high mM concentrations of aliphatic alcohols, 1-O-hexyldiglycerol (HDG) and 1-O-heptyltriglycerol (HTG), are shown to cause enhanced drug transport into brain via disruption of the blood-brain barrier (BBB) in vivo, as determined with an internal carotid artery perfusion method. The intravenous administration of comparable concentrations of HDG or HTG caused no increase in BBB transport of drug. The enhanced transport of drug showed a dependency on molecular weight as 45 mM HTG increased the transport of sucrose, 360 Da, but did not increase the transport of arginine vasopressin (AVP), 1084 Da, although AVP transport across the BBB was increased by 80 mM HDG or HTG. Quasielastic light scattering measurements provided evidence for the formation of vesicular structures in aqueous solutions containing high mM concentrations of the HDG or HTG. In summary, these studies demonstrate BBB disruption following the internal carotid arterial infusion of high mM concentrations of membrane active alkyl glycerols.
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DOI
10.1080/1061186021000038337
Appears in Collections:
약학대학 > 약학과 > Journal papers
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