Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 유권 | - |
dc.date.accessioned | 2016-08-28T11:08:43Z | - |
dc.date.available | 2016-08-28T11:08:43Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.other | OAK-742 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218819 | - |
dc.description.abstract | BACKGROUND. Hypoxia up-regulates insulin-like growth factor-2 (IGF-2) and thus stimulates the growth of hepatocellular carcinoma (HCC) cells. In the current study, the authors prospectively evaluated changes in plasma IGF-2 levels in HCC patients after transcatheter arterial chemoembolization (TACE), which usually results in hypoxic insult to liver tissue. The authors also examined the association between changes in plasma IGF-2 levels after TACE and HCC progression, especially in relation to metastasis. METHODS. Plasma IGF-2 levels were measured before and 4 weeks after TACE in 46 patients with HCC. Three months after TACE, the patients were evaluated for the occurrence of metastatic HCC. RESULTS. In 13 of the 46 patients, post-TACE plasma IGF-2 levels decreased by > 20% (Group 1) compared with their basal levels; in 18 patients, the IGF-2 levels changed within 20% (Group 2) and in 15 patients the IGF-2 levels increased by > 20% (Group 3). Plasma IGF-2 levels had a tendency to increase in patients with large-sized tumors, high serum α-fetoprotein (AFP) levels, and the heterogeneous uptake of iodized oil. Metastatic foci were found in 9 patients in Group 3 (60%), in contrast to only 3 patients in Group 2 (17%) and in none of the patients in Group 1 (P = 0.001). On multivariate analysis, higher Child-Pugh scores and increased plasma IGF-2 levels (Group 3) were found to be independent risk factors for metastasis. CONCLUSIONS. Increased plasma IGF-2 levels after TACE, which are common in patients with large-sized tumors and high serum AFP levels, appear to be associated with the occurrence of metastatic HCC after TACE. © 2001 American Cancer Society. | - |
dc.language | English | - |
dc.title | Association between insulin-like growth factor-2 and metastases after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: A prospective study | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 91 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2386 | - |
dc.relation.lastpage | 2393 | - |
dc.relation.journaltitle | Cancer | - |
dc.identifier.doi | 10.1002/1097-0142(20010615)91:12< | - |
dc.identifier.doi | 2386::AID-CNCR1272> | - |
dc.identifier.doi | 3.0.CO | - |
dc.identifier.doi | 2-4 | - |
dc.identifier.wosid | WOS:000169348200023 | - |
dc.identifier.scopusid | 2-s2.0-0035876139 | - |
dc.author.google | Song B.-C. | - |
dc.author.google | Chung Y.-H. | - |
dc.author.google | Kim J.A. | - |
dc.author.google | Lee H.C. | - |
dc.author.google | Yoon H.-K. | - |
dc.author.google | Sung K.-B. | - |
dc.author.google | Hyunyang S. | - |
dc.author.google | Yoo K. | - |
dc.author.google | Lee Y.S. | - |
dc.author.google | Suh D.J. | - |
dc.contributor.scopusid | 유권(7202592827) | - |
dc.date.modifydate | 20220901081003 | - |