Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승주 | * |
dc.contributor.author | 이순남 | * |
dc.contributor.author | 이미애 | * |
dc.contributor.author | 정화순 | * |
dc.contributor.author | 성주명 | * |
dc.contributor.author | 유은선 | * |
dc.contributor.author | 허정원 | * |
dc.contributor.author | 남은미 | * |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2000 | * |
dc.identifier.issn | 1066-5099 | * |
dc.identifier.other | OAK-471 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218661 | - |
dc.description.abstract | The aim of the present study is to evaluate the kinetics of CD34+ cells and investigate the potential modulation of CD44 and CD31 expression on CD34+ cells during continuous i.v. administration of G-CSF, thus to elucidate the possible mechanism of peripheral blood progenitor cell (PBPC) mobilization. Fifteen healthy donors were enrolled in this study. G-CSF (103 μg/kg/day) was administered for four consecutive days through continuous 24- h i.v. infusion. For measurement of complete blood counts, CD34+ cell levels and their expression of CD44 and CD31, PB sampling was performed immediately before the administration of G-CSF (steady-state) and after 4, 8, 24, 48, 72, 96, and 120 h of G-CSF administration. The percentage and absolute number of CD34+ cells significantly increased at day 3 (0.55 ± 0.09%, 51.12 ± 24.83 x 103/ml) and day 4 (0.47 ± 0.09%, 46.66 ± 24.93 x 103/ml), compared to the steady-state level (0.06 ± 0.09%, 2.03 ± 5.69 x 103/ml). At day 3 to day 5 following the onset of G-CSF administration, a strong decrease of CD44 and CD31 expression was observed on mobilized CD34+ cells compared to controls: the relative fluorescence intensity of CD44 and CD31 was, respectively, 50%-70% and 40%-90% lower than that of controls. We conclude that continuous i.v. administration of G-CSF apparently results in more rapid mobilization of CD34+ cells, and downregulation of CD44 and CD31 on CD34+ cells is likely to be involved in the mobilization of PBPC after treatment with G-CSF. | * |
dc.language | English | * |
dc.title | Mobilization kinetics of CD34+ cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G- CSF in normal donors | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 281 | * |
dc.relation.lastpage | 286 | * |
dc.relation.journaltitle | Stem Cells | * |
dc.identifier.wosid | WOS:000088417300006 | * |
dc.identifier.scopusid | 2-s2.0-0033858358 | * |
dc.author.google | Lee S. | * |
dc.author.google | Im S.-A. | * |
dc.author.google | Yoo E.-S. | * |
dc.author.google | Nam E.-M. | * |
dc.author.google | Lee M.-A. | * |
dc.author.google | Ahn J.-Y. | * |
dc.author.google | Huh J.-W. | * |
dc.author.google | Kim D.-Y. | * |
dc.author.google | Lee S.-N. | * |
dc.author.google | Kim M.-J. | * |
dc.author.google | Lee S.-J. | * |
dc.author.google | Chung W.-S. | * |
dc.author.google | Seong C.-M. | * |
dc.contributor.scopusid | 이승주(54583939900;57219300715) | * |
dc.contributor.scopusid | 이순남(8422735900;56949372000) | * |
dc.contributor.scopusid | 이미애(7409114044) | * |
dc.contributor.scopusid | 정화순(7401983201;54885771500) | * |
dc.contributor.scopusid | 성주명(7005537065) | * |
dc.contributor.scopusid | 유은선(20936704200) | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 남은미(7005824288;57226666155) | * |
dc.date.modifydate | 20240301081003 | * |