Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2016-08-28T11:08:27Z | - |
dc.date.available | 2016-08-28T11:08:27Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1054-2523 | - |
dc.identifier.other | OAK-461 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218656 | - |
dc.description.abstract | 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2. | - |
dc.language | English | - |
dc.title | 7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 10 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 40 | - |
dc.relation.lastpage | 49 | - |
dc.relation.journaltitle | Medicinal Chemistry Research | - |
dc.identifier.wosid | WOS:000088050800005 | - |
dc.identifier.scopusid | 2-s2.0-0033913872 | - |
dc.author.google | Ryu C.-K. | - |
dc.author.google | Lee I.-K. | - |
dc.author.google | Jung S.-H. | - |
dc.author.google | Kang H.-Y. | - |
dc.author.google | Lee C.-O. | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20170901081001 | - |