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7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
- Title
- 7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines
- Authors
- Ryu C.-K.; Lee I.-K.; Jung S.-H.; Kang H.-Y.; Lee C.-O.
- Ewha Authors
- 유충규
- SCOPUS Author ID
- 유충규
- Issue Date
- 2000
- Journal Title
- Medicinal Chemistry Research
- ISSN
- 1054-2523
- Citation
- Medicinal Chemistry Research vol. 10, no. 1, pp. 40 - 49
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- 6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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