View : 581 Download: 0
Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure
- Title
- Pharmacokinetic changes of cyclosporine after intravenous and oral administration to rats with uranyl nitrate-induced acute renal failure
- Authors
- Lee Y.H.; Park K.H.; Ku Y.S.
- Ewha Authors
- 구영순
- SCOPUS Author ID
- 구영순
- Issue Date
- 2000
- Journal Title
- International Journal of Pharmaceutics
- ISSN
- 0378-5173
- Citation
- International Journal of Pharmaceutics vol. 194, no. 2, pp. 221 - 227
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The effects of renal failure on the pharmacokinetics of cyclosporine were investigated after intravenous, 30 mg/kg, and oral, 100 mg/kg, administration of the drug using a rat model of uranyl nitrate-induced acute renal failure (U-ARF). After intravenous administration to rats with U-ARF, the volume of distribution at steady state (1.97 vs. 2.56 l/kg) was significantly smaller, and the area under the blood concentration-time curve (348 vs. 296 μg h/ml) tended to be greater and total body clearance (0.0851 vs. 0.102 l/h per kg) tended to be slower than those in control rats. After oral administration, the pharmacokinetic parameters were not significantly different between the control rats and rats with U-ARF, suggesting that U-ARF did not considerably affect the pharmacokinetics of cyclosporine after oral administration. (C) 2000 Elsevier Science B.V.
- DOI
- 10.1016/S0378-5173(99)00382-8
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML