A new and concise synthetic route to an enantiopure (+)-conduritol-E derivative from diethyl L-tartrate

Abstract

(+)-(1R,2R,3S,6S)-3,6-Di-O-methyl conduritol-E was efficiently synthesized in enantiomerically pure form starting from diethyl L-tartrate in 33% total yield using a ring-closing olefin metathesis reaction as one of the key steps. (C) 1999 Elsevier Science Ltd.