Synthesis and antiviral activity of apio dideoxy nucleosides with azido or amino substituent

Abstract

Novel apio dideoxynucleosides with azido or amino substituent were synthesized starting from 1,3-dihydroxyacetone utilizing an acid-catalyzed 1,4conjugated addition as a key step and evaluated for antiviral activity. Unfortunately, they were found to be neither active against HIV-1, HSV-1,2 and poliovirus nor toxic.