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dc.contributor.author김승철-
dc.contributor.author김윤환-
dc.date.accessioned2016-08-28T11:08:59Z-
dc.date.available2016-08-28T11:08:59Z-
dc.date.issued2016-
dc.identifier.issn1976-9148-
dc.identifier.issn2005-4483-
dc.identifier.otherOAK-19012-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218362-
dc.description.abstractIt has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established a total synthesis method. Using those conditions, we further synthesized various analogs with structural similarity to KTH-13. In this study, we aimed to test their anti-cancer activity by measuring anti-proliferative and pro-apoptotic activities. Of 8 compounds tested, 4-methyl-2,6-bis(1-phenylethyl)phenol (KTH-13-Me) exhibited the strongest anti-proliferative activity toward MDA-MB 231 cells. KTH-13-Me also similarly suppressed the survival of various cancer cell lines, including C6 glioma, HCT-15, and LoVo cells. Treatment of KTH-13-Me induced several apoptotic signs in 06. glioma cells, such as morphological changes, induction of apoptotic bodies, and nuclear fragmentation and chromatin condensation. Concordantly, early-apoptotic cells were also identified by staining with FITC-Annexin V/Pl. Moreover, KTH-13-Me highly enhanced the activation of caspase-3 and caspase-9, and decreased the protein level of Bcl-2. In addition, the phosphorylation levels of Src and STAT3 were diminished in KTH-13-Me-treated C6 cells. Therefore, these results suggest that KTH-13-Me can be developed as a novel anti-cancer drug capable of blocking proliferation, inducing apoptosis, and blocking cell survival signaling in cancer cells.-
dc.languageEnglish-
dc.publisherKOREAN SOC APPLIED PHARMACOLOGY-
dc.subject4-methyl-2,6-bis(1-phenylethyl)pbenol-
dc.subjectApoptotis-
dc.subjectAnti-cancer activity-
dc.subjectCordyceps Bassiana-
dc.titleAnti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume24-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage402-
dc.relation.lastpage409-
dc.relation.journaltitleBIOMOLECULES & THERAPEUTICS-
dc.identifier.doi10.4062/biomolther.2015.166-
dc.identifier.wosidWOS:000379378600007-
dc.identifier.scopusid2-s2.0-84977473029-
dc.author.googleSung, Nak Yoon-
dc.author.googleKim, Seung Cheol-
dc.author.googleKim, Yun Hwan-
dc.author.googleKim, Gihyeon-
dc.author.googleLee, Yunmi-
dc.author.googleSung, Gi-Ho-
dc.author.googleKim, Ji Hye-
dc.author.googleYang, Woo Seok-
dc.author.googleKim, Mi Seon-
dc.author.googleBaek, Kwang-Soo-
dc.author.googleKim, Jong-Hoon-
dc.author.googleChoi, Jae Youl-
dc.contributor.scopusid김승철(35264000100)-
dc.contributor.scopusid김윤환(55763947200)-
dc.date.modifydate20190308081000-
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의과대학 > 의학과 > Journal papers
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