Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승철 | * |
dc.contributor.author | 김윤환 | * |
dc.date.accessioned | 2016-08-28T11:08:59Z | - |
dc.date.available | 2016-08-28T11:08:59Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.issn | 2005-4483 | * |
dc.identifier.other | OAK-19012 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218362 | - |
dc.description.abstract | It has been found that 4-isopropyl-2,6-bis(1-phenylethyl)phenol (KTH-13), a novel compound isolated from Cordyceps bassiana, is able to suppress tumor cell proliferation by inducing apoptosis. To mass-produce this compound, we established a total synthesis method. Using those conditions, we further synthesized various analogs with structural similarity to KTH-13. In this study, we aimed to test their anti-cancer activity by measuring anti-proliferative and pro-apoptotic activities. Of 8 compounds tested, 4-methyl-2,6-bis(1-phenylethyl)phenol (KTH-13-Me) exhibited the strongest anti-proliferative activity toward MDA-MB 231 cells. KTH-13-Me also similarly suppressed the survival of various cancer cell lines, including C6 glioma, HCT-15, and LoVo cells. Treatment of KTH-13-Me induced several apoptotic signs in 06. glioma cells, such as morphological changes, induction of apoptotic bodies, and nuclear fragmentation and chromatin condensation. Concordantly, early-apoptotic cells were also identified by staining with FITC-Annexin V/Pl. Moreover, KTH-13-Me highly enhanced the activation of caspase-3 and caspase-9, and decreased the protein level of Bcl-2. In addition, the phosphorylation levels of Src and STAT3 were diminished in KTH-13-Me-treated C6 cells. Therefore, these results suggest that KTH-13-Me can be developed as a novel anti-cancer drug capable of blocking proliferation, inducing apoptosis, and blocking cell survival signaling in cancer cells. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | * |
dc.subject | 4-methyl-2,6-bis(1-phenylethyl)pbenol | * |
dc.subject | Apoptotis | * |
dc.subject | Anti-cancer activity | * |
dc.subject | Cordyceps Bassiana | * |
dc.title | Anti-Proliferative and Pro-Apoptotic Activities of 4-Methyl-2,6-bis(1-phenylethyl)phenol in Cancer Cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 402 | * |
dc.relation.lastpage | 409 | * |
dc.relation.journaltitle | BIOMOLECULES & THERAPEUTICS | * |
dc.identifier.doi | 10.4062/biomolther.2015.166 | * |
dc.identifier.wosid | WOS:000379378600007 | * |
dc.identifier.scopusid | 2-s2.0-84977473029 | * |
dc.author.google | Sung, Nak Yoon | * |
dc.author.google | Kim, Seung Cheol | * |
dc.author.google | Kim, Yun Hwan | * |
dc.author.google | Kim, Gihyeon | * |
dc.author.google | Lee, Yunmi | * |
dc.author.google | Sung, Gi-Ho | * |
dc.author.google | Kim, Ji Hye | * |
dc.author.google | Yang, Woo Seok | * |
dc.author.google | Kim, Mi Seon | * |
dc.author.google | Baek, Kwang-Soo | * |
dc.author.google | Kim, Jong-Hoon | * |
dc.author.google | Choi, Jae Youl | * |
dc.contributor.scopusid | 김승철(35264000100) | * |
dc.contributor.scopusid | 김윤환(55763947200) | * |
dc.date.modifydate | 20240220115825 | * |