Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.contributor.author | 서석효 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 김관창 | * |
dc.date.accessioned | 2016-08-28T11:08:58Z | - |
dc.date.available | 2016-08-28T11:08:58Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0031-3998 | * |
dc.identifier.issn | 1530-0447 | * |
dc.identifier.other | OAK-18999 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218359 | - |
dc.description.abstract | BACKGROUND: Pulmonary arterial hypertension (PAH) progressively leads to increases in pulmonary vasoconstriction. Modafinil plays a role in vasorelaxation and blocking KCa3.1 channel with a result of elevating intracellular cyclic adenosine monophosphate (cAMP) levels. The purpose of this study is to evaluate the effects on modafinil in monocrotaline (MCT)-induced PAH rat. METHODS: The rats were separated into three groups: the control group, the monocrotaline (M) group (MCT 60 mg/kg), and the modafinil (MD) group (MCT 60 mg/kg + modafinil). RESULTS: Reduced right ventricular pressure (RVP) was observed in the MD group. Right ventricular hypertrophy was improved in the MD group. Reduced number of intra-acinar pulmonary arteries and medial wall thickness were noted in the MD group. After the administration of modafinil, protein expressions of endothelin-1 (ET-1), endothelin receptor A (ERA) and KCa3.1 channel were significantly reduced. Modafinil suppressed pulmonary artery smooth muscle cell (PASMC) proliferation via cAMP and KCa3.1 channel. Additionally, we confirmed protein expressions such as Bcl-2-associated X, vascular endothelial growth factor, tumor necrosis factor-alpha, and interleukin-6 were reduced in the MD group. CONCLUSION: Modafinil improved PAH by vasorelaxation and a decrease in medial thickening via ET-1, ERA, and KCa3.1 down regulation. This is a meaningful study of a modafinil in PAH model. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Modafinil improves monocrotaline-induced pulmonary hypertension rat model | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 80 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 119 | * |
dc.relation.lastpage | 127 | * |
dc.relation.journaltitle | PEDIATRIC RESEARCH | * |
dc.identifier.doi | 10.1038/pr.2016.38 | * |
dc.identifier.wosid | WOS:000379377900018 | * |
dc.identifier.scopusid | 2-s2.0-84976871766 | * |
dc.author.google | Lee, Hyeryon | * |
dc.author.google | Kim, Kwan Chang | * |
dc.author.google | Cho, Min-Sun | * |
dc.author.google | Suh, Suk-hyo | * |
dc.author.google | Hong, Young Mi | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 서석효(55666113100) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 김관창(36652690000) | * |
dc.date.modifydate | 20240415130647 | * |