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Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease
- Title
- Vitamin D Deficiency Is Associated with Rapid Decline in Exercise Capacity in Male Patients with Chronic Obstructive Pulmonary Disease
- Authors
- Kim, Changhwan; Jung, Ji Ye; Kim, Young Sam; Lee, Jae Seung; Rhee, Chin Kook; Lee, Jin Hwa; Lee, Ji-Hyun; Kim, Tae-Hyung; Lim, Seong Yong; Sheen, Seung Soo; Yoo, Kwang Ha; Seo, Joon Beom; Oh, Yeon-Mok; Lee, Sang-Do; Park, Yong Bum
- Ewha Authors
- 이진화
- SCOPUS Author ID
- 이진화
- Issue Date
- 2016
- Journal Title
- RESPIRATION
- ISSN
- 0025-7931
1423-0356
- Citation
- RESPIRATION vol. 91, no. 5, pp. 351 - 358
- Keywords
- Chronic obstructive pulmonary disease; Vitamin D deficiency; Exercise capacity; Six-minute walk distance
- Publisher
- KARGER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Vitamin D is suggested to play a role in airway and systemic inflammation in chronic obstructive pulmonary disease (COPD). Low serum 25-hydroxyvitamin D (25-OHD) levels have been suggested to be associated with lower lung function and poorer exercise capacity in COPD. Objectives: The main purpose of this study was to investigate the effects of vitamin D deficiency on the change in exercise capacity in male COPD patients. Methods: A total of 156 male subjects were selected from the Korean Obstructive Lung Disease cohort. Vitamin D deficiency was subdivided into three subgroups: mild, moderate, and severe deficiency groups. Rapid decline was defined as an annual rate of change in exercise capacity >= 17 m. Exercise capacity was assessed by 6-minute walk distance (6MWD). Results: Significant differences were observed in the serum levels of 25-OHD, the number of patients with vitamin D sufficiency, and moderate-to-severe deficiency between rapid decliners (n = 40) and non-rapid decliners (n = 116). No differences were found between the groups for age, smoking status, lung function, and 6MWD. Multivariate analysis showed that vitamin D deficiency was independently related to rapid decline in exercise capacity (p = 0.028). A statistically significant difference was observed among the subgroups of vitamin D deficiency in terms of the change in exercise capacity (p < 0.001). The annual decline in exercise capacity was prominent in the severe deficiency group (23.1 m/year). Conclusion: This study shows that vitamin D deficiency is associated with rapid decline in exercise capacity in male patients with COPD. (C) 2016 S. Karger AG, Basel
- DOI
- 10.1159/000445266
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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