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Reproductive Factors Predicting Angiographic Obstructive Coronary Artery Disease: The KoRean wOmen'S Chest Pain rEgistry (KoROSE)
- Title
- Reproductive Factors Predicting Angiographic Obstructive Coronary Artery Disease: The KoRean wOmen'S Chest Pain rEgistry (KoROSE)
- Authors
- Kim, Hack-Lyoung; Kim, Myung-A; Shim, Wan-Joo; Park, Seong Mi; Kim, Yong Hyun; Na, Jin Oh; Shin, Mi Seung; Kim, Yong-Jin; Yoon, Hyun Ju; Shin, Gil Ja; Cho, Yunkyung; Kim, Sung-Eun; Hong, Kyung-Soon; Cho, Kyoung Im
- Ewha Authors
- 신길자
- SCOPUS Author ID
- 신길자
- Issue Date
- 2016
- Journal Title
- JOURNAL OF WOMENS HEALTH
- ISSN
- 1540-9996
1931-843X
- Citation
- JOURNAL OF WOMENS HEALTH vol. 25, no. 5, pp. 443 - 448
- Publisher
- MARY ANN LIEBERT, INC
- Indexed
- SCIE; SSCI; SCOPUS
- Document Type
- Article
- Abstract
- Background: Whether reproductive factors are associated with coronary artery disease (CAD) has been debated. The aim of this study was to investigate etiologic associations of a wide range of reproductive factors of women with the presence of angiographic obstructive CAD. Materials and Methods: Study data were obtained from a nationwide registry that enrolled 687 Korean women (59.9 +/- 11.4 years) with chest pain undergoing invasive coronary angiography (ICA). Obstructive CAD was defined as >= 50% luminal stenosis of one or more epicardial coronary arteries in ICA. Information on reproductive history, including ages at menarche and menopause, duration of reproductive capacity, number of pregnancies, hormonal replacement therapy, and history of twin pregnancy, was obtained using a standardized questionnaire. Results: A total of 178 women (25.9%) had obstructive CAD. Multivariable logistic regression analysis identified that later age at menarche (odds ratio [OR] = 1.265, 95% confidence interval [CI] = 1.064-1.504, p = 0.008, per year) and increased number of pregnancies (OR = 1.223, 95% CI = 1.026-1.457, p = 0.025, per pregnancy) were the independent predictors of obstructive CAD even after controlling for potential confounders, including age, diabetes mellitus, hypertension, dyslipidemia, renal function, high-density lipoprotein level, white blood cell count, hemoglobin, and E/c'. Conclusions: Later age at menarche and increased number of pregnancies may be reproductive risk factors for angiographic obstructive CAD, suggesting the important role of hormonal status in the development of CAD.
- DOI
- 10.1089/jwh.2015.5381
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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