Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | * |
dc.contributor.author | 장준 | * |
dc.contributor.author | 김희정 | * |
dc.contributor.author | 이제진 | * |
dc.date.accessioned | 2016-08-27T04:08:06Z | - |
dc.date.available | 2016-08-27T04:08:06Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0270-7306 | * |
dc.identifier.issn | 1098-5549 | * |
dc.identifier.other | OAK-18414 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218156 | - |
dc.description.abstract | This study is designed to examine the cellular functions of human Fas-associated factor 1 (FAF1) containing multiple ubiquitinrelated domains. Microarray analyses revealed that interferon-stimulated genes related to the antiviral response are significantly increased in FAF1-knockdown HeLa cells. Silencing FAF1 enhanced the poly(I.C)- and respiratory syncytial virus (RSV)-induced production of type I interferons (IFNs), the target genes of interferon regulator factor 3 (IRF3). IRF3 is a key transcription factor in IFN-beta signaling responsible for the host innate immune response. This study also found that FAF1 and IRF3 physically associate with IPO5/importin-beta 3 and that overexpression of FAF1 reduces the interaction between IRF3 and IPO5/importin-beta 3. These findings suggest that FAF1 negatively regulates IRF3-mediated IFN-beta production and the antiviral innate immune response by regulating nuclear translocation of IRF3. We conclude that FAF1 plays a novel role in negatively regulating virus-induced IFN-beta production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus. | * |
dc.language | English | * |
dc.publisher | AMER SOC MICROBIOLOGY | * |
dc.title | Fas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 36 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1136 | * |
dc.relation.lastpage | 1151 | * |
dc.relation.journaltitle | MOLECULAR AND CELLULAR BIOLOGY | * |
dc.identifier.doi | 10.1128/MCB.00744-15 | * |
dc.identifier.wosid | WOS:000372331400007 | * |
dc.identifier.scopusid | 2-s2.0-84962203785 | * |
dc.author.google | Song, Soonhwa | * |
dc.author.google | Lee, Jae-Jin | * |
dc.author.google | Kim, Hee-Jung | * |
dc.author.google | Lee, Jeong Yoon | * |
dc.author.google | Chang, Jun | * |
dc.author.google | Lee, Kong-Joo | * |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | * |
dc.contributor.scopusid | 장준(8735999100) | * |
dc.contributor.scopusid | 김희정(57206210649) | * |
dc.contributor.scopusid | 이제진(55891775900) | * |
dc.date.modifydate | 20231120165756 | * |