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dc.contributor.author이공주*
dc.contributor.author장준*
dc.contributor.author김희정*
dc.contributor.author이제진*
dc.date.accessioned2016-08-27T04:08:06Z-
dc.date.available2016-08-27T04:08:06Z-
dc.date.issued2016*
dc.identifier.issn0270-7306*
dc.identifier.issn1098-5549*
dc.identifier.otherOAK-18414*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218156-
dc.description.abstractThis study is designed to examine the cellular functions of human Fas-associated factor 1 (FAF1) containing multiple ubiquitinrelated domains. Microarray analyses revealed that interferon-stimulated genes related to the antiviral response are significantly increased in FAF1-knockdown HeLa cells. Silencing FAF1 enhanced the poly(I.C)- and respiratory syncytial virus (RSV)-induced production of type I interferons (IFNs), the target genes of interferon regulator factor 3 (IRF3). IRF3 is a key transcription factor in IFN-beta signaling responsible for the host innate immune response. This study also found that FAF1 and IRF3 physically associate with IPO5/importin-beta 3 and that overexpression of FAF1 reduces the interaction between IRF3 and IPO5/importin-beta 3. These findings suggest that FAF1 negatively regulates IRF3-mediated IFN-beta production and the antiviral innate immune response by regulating nuclear translocation of IRF3. We conclude that FAF1 plays a novel role in negatively regulating virus-induced IFN-beta production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 from the cytosol to the nucleus.*
dc.languageEnglish*
dc.publisherAMER SOC MICROBIOLOGY*
dc.titleFas-Associated Factor 1 Negatively Regulates the Antiviral Immune Response by Inhibiting Translocation of Interferon Regulatory Factor 3 to the Nucleus*
dc.typeArticle*
dc.relation.issue7*
dc.relation.volume36*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage1136*
dc.relation.lastpage1151*
dc.relation.journaltitleMOLECULAR AND CELLULAR BIOLOGY*
dc.identifier.doi10.1128/MCB.00744-15*
dc.identifier.wosidWOS:000372331400007*
dc.identifier.scopusid2-s2.0-84962203785*
dc.author.googleSong, Soonhwa*
dc.author.googleLee, Jae-Jin*
dc.author.googleKim, Hee-Jung*
dc.author.googleLee, Jeong Yoon*
dc.author.googleChang, Jun*
dc.author.googleLee, Kong-Joo*
dc.contributor.scopusid이공주(7501497635;57191532162)*
dc.contributor.scopusid장준(8735999100)*
dc.contributor.scopusid김희정(57206210649)*
dc.contributor.scopusid이제진(55891775900)*
dc.date.modifydate20231120165756*


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