Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤여준 | * |
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2016-08-27T04:08:05Z | - |
dc.date.available | 2016-08-27T04:08:05Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0040-4039 | * |
dc.identifier.other | OAK-18404 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218152 | - |
dc.description.abstract | Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively, were isolated from marine sediments collected off shore near La Jolla, California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 1D and 2D NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an alpha-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC50 value of 13 mu M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophilic genus Streptomonospora. (C) 2016 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Streptomonospora sp. | * |
dc.subject | Nocardiopsis sp. | * |
dc.subject | alpha-Pyrone | * |
dc.subject | Anti-inflammatory activity | * |
dc.title | Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae | * |
dc.type | Article | * |
dc.relation.issue | 18 | * |
dc.relation.volume | 57 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1997 | * |
dc.relation.lastpage | 2000 | * |
dc.relation.journaltitle | TETRAHEDRON LETTERS | * |
dc.identifier.doi | 10.1016/j.tetlet.2016.03.084 | * |
dc.identifier.wosid | WOS:000374622800014 | * |
dc.identifier.scopusid | 2-s2.0-84962124794 | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Han, Chulkyeong | * |
dc.author.google | Lee, Tae Gu | * |
dc.author.google | Chin, Jungwook | * |
dc.author.google | Choi, Hyukjae | * |
dc.author.google | Lee, Wonjae | * |
dc.author.google | Paik, Man Jeong | * |
dc.author.google | Won, Dong Hwan | * |
dc.author.google | Jeong, Gyusang | * |
dc.author.google | Ko, Jaeyoung | * |
dc.author.google | Yoong, Yeo Joon | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Fenical, William | * |
dc.author.google | Kang, Heonjoong | * |
dc.contributor.scopusid | 윤여준(7402126465) | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |