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dc.contributor.author류재상-
dc.date.accessioned2016-08-27T04:08:05Z-
dc.date.available2016-08-27T04:08:05Z-
dc.date.issued2016-
dc.identifier.issn0968-0896-
dc.identifier.issn1464-3391-
dc.identifier.otherOAK-18398-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218147-
dc.description.abstractA series of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives were designed, synthesized, and evaluated for the Aurora kinase inhibitory activities. The novel hinge-binder tethered 1,2,3-triazolylsalicylamide scaffold was effectively assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). A variety of alkynes with hinge binders were used to search proper structures-binding relationship to the hinge region. The synthesized 1,2,3-triazolylsalicylamide derivatives showed significant Aurora kinase inhibitory activity. In particular, 8a inhibited Aurora A kinase with an IC50 value of 0.284 mu M, whereas 8m inhibited Aurora B kinase with an IC50 value of 0.364 mu M. (C) 2016 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectAurora kinase-
dc.subjectClick chemistry-
dc.subjectHinge-binder-
dc.subject1,2,3-Triazole-
dc.subjectAnticancer-
dc.titleDesign, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume24-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2114-
dc.relation.lastpage2124-
dc.relation.journaltitleBIOORGANIC & MEDICINAL CHEMISTRY-
dc.identifier.doi10.1016/j.bmc.2016.03.042-
dc.identifier.wosidWOS:000373740500014-
dc.identifier.scopusid2-s2.0-84962052750-
dc.author.googleJeong, Yunkyung-
dc.author.googleLee, Jooyeon-
dc.author.googleRyu, Jae-Sang-
dc.contributor.scopusid류재상(36081118200)-
dc.date.modifydate20210929133322-
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약학대학 > 약학과 > Journal papers
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