Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지수 | - |
dc.date.accessioned | 2016-08-27T04:08:00Z | - |
dc.date.available | 2016-08-27T04:08:00Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | OAK-16631 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218107 | - |
dc.description.abstract | The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 11 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | PLOS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0150283 | - |
dc.identifier.wosid | WOS:000371274400117 | - |
dc.identifier.scopusid | 2-s2.0-84960465745 | - |
dc.author.google | Kim, Kwangwoo | - |
dc.author.google | Bang, So-Young | - |
dc.author.google | Yoo, Dae Hyun | - |
dc.author.google | Cho, Soo-Kyung | - |
dc.author.google | Choi, Chan-Bum | - |
dc.author.google | Sung, Yoon-Kyoung | - |
dc.author.google | Kim, Tae-Hwan | - |
dc.author.google | Jun, Jae-Bum | - |
dc.author.google | Kang, Young Mo | - |
dc.author.google | Suh, Chang-Hee | - |
dc.author.google | Shim, Seung-Cheol | - |
dc.author.google | Lee, Shin-Seok | - |
dc.author.google | Lee, Jisoo | - |
dc.author.google | Chung, Won Tae | - |
dc.author.google | Kim, Seong-Kyu | - |
dc.author.google | Choe, Jung-Yoon | - |
dc.author.google | Nath, Swapan K. | - |
dc.author.google | Lee, Hye-Soon | - |
dc.author.google | Bae, Sang-Cheol | - |
dc.contributor.scopusid | 이지수(14424388700) | - |
dc.date.modifydate | 20230201112642 | - |