Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.contributor.author | 이은정 | * |
dc.date.accessioned | 2016-08-27T04:08:56Z | - |
dc.date.available | 2016-08-27T04:08:56Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1557-1890 | * |
dc.identifier.issn | 1557-1904 | * |
dc.identifier.other | OAK-16538 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218063 | - |
dc.description.abstract | Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, but further study is necessary for elucidating the detailed mechanisms of these effects. In this study, we examined the anti-inflammatory effect of tangeretin in lipopolysaccharide (LPS)-stimulated microglia. We first observed that tangeretin inhibited LPS-induced production of nitric oxide, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1 beta, as well as LPS-induced mRNA expression of inducible nitric oxide synthases and cytokines. Additionally, we found that the activities, mRNA levels, and protein levels of matrix metalloproteinase (MMP)-3 and MMP-8 were inhibited, while the expression of tissue inhibitor of metalloproteinase-2 was enhanced by tangeretin in LPS-stimulated microglia. Further mechanistic study showed that tangeretin suppressed LPS-induced phosphorylation of mitogen-activated protein kinases and Akt. Also, tangeretin inhibited nuclear factor-kappa B by upregulating sirtuin 1 and 5'-adenosine monophosphate-activated protein kinase. We further demonstrated the antioxidant effect of tangeretin by showing that tangeretin inhibited reactive oxygen species production and p47(phox) phosphorylation, while enhancing the expression of heme oxygenase-1 and the DNA binding activity of nuclear factor-erythroid 2-related factor 2 to the antioxidant response element in LPS-stimulated microglia. Taken together, the results of the present study demonstrate that tangeretin possesses a potent anti-inflammatory and antioxidant effect in microglia. | * |
dc.language | English | * |
dc.publisher | SPRINGER | * |
dc.subject | Tangeretin | * |
dc.subject | Microglia | * |
dc.subject | Anti-inflammation | * |
dc.subject | Antioxidant | * |
dc.subject | MMP | * |
dc.subject | Molecular mechanism | * |
dc.title | Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 11 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 294 | * |
dc.relation.lastpage | 305 | * |
dc.relation.journaltitle | JOURNAL OF NEUROIMMUNE PHARMACOLOGY | * |
dc.identifier.doi | 10.1007/s11481-016-9657-x | * |
dc.identifier.wosid | WOS:000375078900006 | * |
dc.identifier.scopusid | 2-s2.0-84959104426 | * |
dc.author.google | Lee, Yu Young | * |
dc.author.google | Lee, Eun-Jung | * |
dc.author.google | Park, Jin-Sun | * |
dc.author.google | Jang, Se-Eun | * |
dc.author.google | Kim, Dong-Hyun | * |
dc.author.google | Kim, Hee-Sun | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.contributor.scopusid | 이은정(57212665881) | * |
dc.date.modifydate | 20240215165648 | * |