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The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo
- The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo
- Hwang Y.-H.; Kang K.-Y.; Lee S.-J.; Nam S.-J.; Son Y.-J.; Yee S.-T.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Molecules vol. 21, no. 1
- Alisma canaliculatum; Alisol a 24-acetate; Bone loss; Osteoporosis; Regulator t cell; Traditional Korean medicine
- MDPI AG
- SCIE; SCOPUS
- Document Type
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- Alisma canaliculatum is a herb commonly used in traditional Korean medicine, and has been shown in scientific studies to have antitumor, diuretic hepatoprotective, and antibacterial effects. Recently, the anti-osteoclastogenesis of alisol A 24-acetate from Alisma canaliculatum was investigated in vitro. However, the influence of alisol A 24-acetate on osteoporosis in animals has not been investigated. The present study was undertaken to investigate the anti-osteoporotic effect of alisol A 24-acetate on bone mass in ovariectomized (OVX) mice and to identify the mechanism responsible for its effects. OVX mice were treated daily with 0.5 or 2 μg/g of alisol A 24-acetate for a period of six weeks. It was found that these administrations significantly suppressed osteoporosis in OVX mice and improved bone morphometric parameters. The serum estradiol, bone alkaline phosphatase levels, regulatory T/Th17 cell numbers were significantly increased by alisol A 24-acetate as compared with untreated OVX mice. In addition, TRAP activity was inhibited by alisol A 24-acetate in OVX mice. These results suggest alisol A 24-acetate effectively prevents bone loss in OVX mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis.
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