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Effect of Immunotherapy on Seizure Outcome in Patients with Autoimmune Encephalitis: A Prospective Observational Registry Study

Title
Effect of Immunotherapy on Seizure Outcome in Patients with Autoimmune Encephalitis: A Prospective Observational Registry Study
Authors
Byun, Jung-IckLee, Soon-TaeJung, Keun-HwaSunwoo, Jun-SangMoon, JangsupLim, Jung-AhLee, Doo YoungShin, Yong-WonKim, Tae-JoonLee, Keon-JooLee, Woo-JinLee, Han-SangJun, JinsunKim, Dong-YubKim, Man-YoungKim, HyunjinKim, Hyeon JinSuh, Hong IlLee, YoojinKim, Dong WookJeong, Jin HoChoi, Woo ChanBae, Dae WoongShin, Jung-WonJeon, DaejongPark, Kyung-IlJung, Ki-YoungChu, KonLee, Sang Kun
Ewha Authors
문장섭
SCOPUS Author ID
문장섭scopus
Issue Date
2016
Journal Title
PLOS ONE
ISSN
1932-6203JCR Link
Citation
PLOS ONE vol. 11, no. 1
Publisher
PUBLIC LIBRARY SCIENCE
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) and new-onset seizure. Methods Adult (age >= 18 years) patients with AE and new-onset seizure who underwent immunotherapy and were followed-up for at least 6 months were included. Seizure frequency was evaluated at 2-4 weeks and 6 months after the onset of the initial immunotherapy and was categorized as "seizure remission", "> 50% seizure reduction", or "no change" based on the degree of its decrease. Results Forty-one AE patients who presented with new-onset seizure were analysed. At 2-4 weeks after the initial immunotherapy, 51.2% of the patients were seizure free, and 24.4% had significant seizure reduction. At 6 months, seizure remission was observed in 73.2% of the patients, although four patients died during hospitalization. Rituximab was used as a second-line immunotherapy in 12 patients who continued to have seizures despite the initial immunotherapy, and additional seizure remission was achieved in 66.6% of them. In particular, those who exhibited partial response to the initial immunotherapy had a better seizure outcome after rituximab, with low adverse events. Conclusion AE frequently presented as seizure, but only 18.9% of the living patients suffered from seizure at 6 months after immunotherapy. Aggressive immunotherapy can improve seizure outcome in patients with AE.
DOI
10.1371/journal.pone.0146455
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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