Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-27T04:08:46Z | - |
dc.date.available | 2016-08-27T04:08:46Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1472-6882 | * |
dc.identifier.other | OAK-16277 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217965 | - |
dc.description.abstract | Background: Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress. Methods: Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC-MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks. Results: We have standardized 70 % fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 +/- 0.34 mu g/mg; liquiritin (LQ), 14.55 +/- 0.42 mu g/mg; and liquiritigenin (LG), 1.34 +/- 0.02 mu g/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-alpha. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-alpha production was significantly inhibited by licorice. Conclusion: Taken together, our data suggests that protective effect of licorice against alcohol-induced liver injury may be attributed to its anti-inflammatory activity and enhancement of antioxidant defense. | * |
dc.language | English | * |
dc.publisher | BIOMED CENTRAL LTD | * |
dc.subject | Licorice | * |
dc.subject | Alcohol-induced liver injury | * |
dc.subject | Glutathione | * |
dc.subject | TNF-alpha | * |
dc.title | Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease | * |
dc.type | Article | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE | * |
dc.identifier.doi | 10.1186/s12906-016-0997-0 | * |
dc.identifier.wosid | WOS:000368494600001 | * |
dc.identifier.scopusid | 2-s2.0-84955353038 | * |
dc.author.google | Jung, Jae-Chul | * |
dc.author.google | Lee, Yun-Hee | * |
dc.author.google | Kim, Sou Hyun | * |
dc.author.google | Kim, Keuk-Jun | * |
dc.author.google | Kim, Kyung-Mi | * |
dc.author.google | Oh, Seikwan | * |
dc.author.google | Jung, Young-Suk | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |