Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-27T04:08:44Z | - |
dc.date.available | 2016-08-27T04:08:44Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1021-335X | * |
dc.identifier.issn | 1791-2431 | * |
dc.identifier.other | OAK-16264 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217956 | - |
dc.description.abstract | Myristoylated alanine-rich C kinase substrate-like 1 (MARCKSL1) plays a pivotal role in the regulation of apoptosis and has been shown to maintain antitumor and metastasis-suppressive properties. In the present study, we examined the effects of MARCKSL1 as a novel anti-angiogenic agent on the inhibition of angiogenesis-mediated cell migration. MARCKSL1 also reduced vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cell (HUVEC) proliferation, as well as capillary-like tubular structure formation in vitro. MARCKSL1 disrupted phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) in ovarian tumorigenesis. In addition, MARCKSL1 showed potent anti-angiogenic activity and reduced the levels of VEGF and hypoxia-inducible factor la (HIF-1 alpha) expression, an essential regulator of angiogenesis. Consistently, MARCKSL1 decreased VEGF-induced phosphorylation of the PI3K/Akt signaling pathway components, including phosphoinositide-dependent protein kinase 1 (PDK-1), mammalian target of rapamycin (mTOR), tuberous sclerosis complex 2 (TSC-2), p70 ribosomal protein S6 kinase (p7056K), and glycogen synthase kinase 3 beta (GSK-3 beta) protein. Collectively, our results provide evidence for the physiological/biological function of an endothelial cell system involved in angiogenesis through suppression of Akt/PDK-1/mTOR phosphorylation by interaction with VEGFR-2. | * |
dc.language | English | * |
dc.publisher | SPANDIDOS PUBL LTD | * |
dc.subject | MARCKSL1 | * |
dc.subject | anti-angiogenic activity | * |
dc.subject | protein-protein interaction | * |
dc.subject | Akt/PDK-1/mTOR phosphorylation | * |
dc.subject | endothelial cells | * |
dc.title | MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 35 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1041 | * |
dc.relation.lastpage | 1048 | * |
dc.relation.journaltitle | ONCOLOGY REPORTS | * |
dc.identifier.doi | 10.3892/or.2015.4408 | * |
dc.identifier.wosid | WOS:000368049600053 | * |
dc.identifier.scopusid | 2-s2.0-84954305410 | * |
dc.author.google | Kim, Boh-Ram | * |
dc.author.google | Lee, Seung-Hoon | * |
dc.author.google | Park, Mi-Sun | * |
dc.author.google | Seo, Seung-Hee | * |
dc.author.google | Park, Young-Min | * |
dc.author.google | Kwon, Young-Joo | * |
dc.author.google | Rho, Seung-Bae | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |