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Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency

Title
Comparative Analysis of Midtrimester Amniotic Fluid Cytokine Levels to Predict Spontaneous Very Pre-term Birth in Patients with Cervical Insufficiency
Authors
Son, Ga-HyunYou, Young-AhKwon, Eun-JinLee, Keun-YoungKim, Young Ju
Ewha Authors
김영주유영아
SCOPUS Author ID
김영주scopus; 유영아scopus
Issue Date
2016
Journal Title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN
1046-7408JCR Link

1600-0897JCR Link
Citation
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY vol. 75, no. 2, pp. 155 - 161
Keywords
Amniotic fluidcervical insufficiencycytokine
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Problem Few studies have investigated the roles of cytokines and chemokines in women with cervical insufficiency, and those that have done so evaluated only a limited number of cytokines in amniotic fluid. Method of study A retrospective cohort study enrolled 71 patients undergoing physical examination-indicated cerclage to determine whether expanded amniotic fluid cytokine levels predict spontaneous very pre-term birth (<= 32 weeks of gestation) in patients with cervical insufficiency. Analysis of multiple cytokines and chemokines was performed with the multiplex immunoassay. Results Sixty-seven amniotic fluid samples were available for analysis and assayed for 15 cytokines. Thirty-eight (56.7%) patients delivered pre-term. Of these, 26 (38.8%) were spontaneous very pre-term births. Most cytokine levels were significantly increased in the amniotic fluid from the study group when compared with those from controls. The levels of interleukin-1 beta (IL-1 beta), IL-6, IL-7, IL-15, IL-17 alpha, tumour necrosis factor-alpha (TNF-alpha), MIP-1 alpha, and MIP-1 beta were higher in patients with a very pre-term delivery than in those with a late pre-term delivery. IL-1 beta, IL-6, IL-7, IL-17 alpha, TNF-alpha, and cervical dilation were independently associated with a very pre-term birth. Conclusion Intra-amniotic inflammation may contribute to cervical insufficiency, and the severity of inflammation is associated with a very pre-term birth in women with cervical insufficiency.
DOI
10.1111/aji.12451
Appears in Collections:
의과대학 > 의학과 > Journal papers
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