Efficient singlet oxygen generation from sugar pendant C-60 derivatives for photodynamic therapy

Abstract

The amidation reaction between C-60 with an activated ester group (1) and acetylated Glc (AcGlc) with an amino group (2) was performed to yield the target AcGlc-pendant C-60 compound (3). The water soluble deacetylated compound, Glc-pendant C-60 compound (4), exhibited high photocytotoxicity against HeLa cells due to the more efficient singlet oxygen generation as compared with that of Glc-pendant azafulleroids.