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Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study
- Long-Term Outcomes of NSAID-Induced Small Intestinal Injury Assessed by Capsule Endoscopy in Korea: A Nationwide Multicenter Retrospective Study
- Shim, Ki-Nam; Song, Eun Mi; Jeen, Yoon Tae; Kim, Jin-Oh; Jeon, Seong Ran; Chang, Dong Kyung; Song, Hyun Joo; Lim, Yun Jeong; Kim, Jin Soo; Ye, Byong Duk; Park, Cheol Hee; Jeon, Seong Woo; Cheon, Jae Hee; Lee, Kwang Jae; Kim, Ji Hyun; Jang, Byung Ik; Moon, Jeong Seop; Chun, Hoon Jae; Choi, Myung-Gyu; Korean Gut Image Study Grp
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- GUT AND LIVER
- GUT AND LIVER vol. 9, no. 6, pp. 727 - 733
- Anti-inflammatory agents; non-steroidal; Capsule endoscopy; Outcome
- EDITORIAL OFFICE GUT &
- SCIE; SCOPUS; KCI
- Document Type
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- Background/Aims: We evaluated the long-term outcome and clinical course of patients of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by performing capsule endoscopy (CE). Methods: A multicenter retrospective study was conducted using data collected from the CE nationwide database registry, which has been established since 2002. Results: A total of 140 patients (87 males; mean age, 60.6+/-14.8 years) from the CE nationwide database registry (n=2,885) were diagnosed with NSAID-induced small intestinal injury and enrolled in our study. Forty-nine patients (35.0%) presented with a history of aspirin use and an additional 49 (35.0%) were taking NSAIDs without aspirin. The most prominent findings after performing CE were multiple ulcerations (n=82, 58.6%) and erosions or aphthae (n=32, 22.9%). During the follow-up period (mean, 15.9+/-19.0 months; range, 0 to 106 months), NSAID-induced small intestinal injury only recurred in six patients (4.3%). Older age and hypertension were positive predictive factors for recurrence. Conclusions: These results suggest that the recurrence of NSAID-induced small bowel injury was not frequent in the presence of conservative treatment. Therefore, the initial diagnosis using CE and the medication history are important.
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