DSpace at EWHA: Synthesis of stereochemically diverse cyclic analogs of tubulysins

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DC Field	Value	Language
dc.contributor.author	류재상	*
dc.date.accessioned	2016-08-27T04:08:26Z	-
dc.date.available	2016-08-27T04:08:26Z	-
dc.date.issued	2015	*
dc.identifier.issn	0968-0896	*
dc.identifier.issn	1464-3391	*
dc.identifier.other	OAK-15912	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/217762	-
dc.description.abstract	The synthesis of tubulysin analogs containing stereochemically diverse cyclic Tuv moieties is described. A tetrahydropyranyl moiety was incorporated into the Tuv unit by enantioselective hetero Diels-Alder reactions of Danishefsky's diene and thiazole aldehyde. Four different stereoisomers of cyclic Tuv units were used as surrogates for the Tuv moiety. The synthesized stereochemically diverse simplified cyclic analogs were evaluated for the inhibition of tubulin polymerization. (C) 2015 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.publisher	PERGAMON-ELSEVIER SCIENCE LTD	*
dc.subject	Tubulysin	*
dc.subject	Antitumor agents	*
dc.subject	Peptides	*
dc.subject	Asymmetric catalysis	*
dc.subject	Hetero Diels-Alder reaction	*
dc.title	Synthesis of stereochemically diverse cyclic analogs of tubulysins	*
dc.type	Article	*
dc.relation.issue	21	*
dc.relation.volume	23	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	6827	*
dc.relation.lastpage	6843	*
dc.relation.journaltitle	BIOORGANIC & MEDICINAL CHEMISTRY	*
dc.identifier.doi	10.1016/j.bmc.2015.10.003	*
dc.identifier.wosid	WOS:000364437400006	*
dc.identifier.scopusid	2-s2.0-84946110449	*
dc.author.google	Park, Yunjeong	*
dc.author.google	Bae, Song Yi	*
dc.author.google	Hah, Jung-Mi	*
dc.author.google	Lee, Sang Kook	*
dc.author.google	Ryu, Jae-Sang	*
dc.contributor.scopusid	류재상(36081118200)	*
dc.date.modifydate	20231120165709	*