Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이귀용 | * |
dc.contributor.author | 김치효 | * |
dc.contributor.author | 정락경 | * |
dc.contributor.author | 김동연 | * |
dc.contributor.author | 백희정 | * |
dc.contributor.author | 우재희 | * |
dc.date.accessioned | 2016-08-27T04:08:25Z | - |
dc.date.available | 2016-08-27T04:08:25Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.issn | 1598-6357 | * |
dc.identifier.other | OAK-15901 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217756 | - |
dc.description.abstract | Several factors can affect the perioperative immune function. We evaluated the effect of propofol and desflurane anesthesia on the surgery-induced immune perturbation in patients undergoing breast cancer surgery. The patients were randomly assigned to receive propofol (n = 20) or desflurane (n = 20) anesthesia. The total and differential white blood cell counts were determined with lymphocyte subpopulations before and 1 hr after anesthesia induction and at 24 hr postoperatively. Plasma concentrations of interleukin (IL)-2 and IL-4 were also measured. Both propofol and desflurane anesthesia preserved the IL-2/IL-4 and CD4(+)/CD8(+) T cell ratio. Leukocytes were lower in the propofol group than in the desflurane group at 1 hr after induction (median [quartiles], 4.98 [3.87-6.31] vs. 5.84 [5.18-7.94] 10(3)/mu L) and 24 hr postoperatively (6.92 [5.54-6.86] vs. 7.62 [6.22-9.21] 10(3)/mu L). NK cells significantly decreased 1 hr after induction in the propofol group (0.41 [0.34-0.53] to 0.25 [0.21-0.33] 10(3)/mu L), but not in the desflurane group (0.33 [0.29-0.48] to 0.38 [0.30-0.56] 10(3)/mu L). Our findings indicate that both propofol and desflurane anesthesia for breast cancer surgery induce a favorable immune response in terms of preservation of IL-2/IL-4 and CD4(+)/CD8(+) T cell ratio in the perioperative period. With respect to leukocytes and NK cells, desflurane anesthesia is associated with less adverse immune responses than propofol anesthesia during surgery for breast cancer. | * |
dc.language | English | * |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | * |
dc.subject | Propofol | * |
dc.subject | Desflurane | * |
dc.subject | Immune System | * |
dc.subject | Breast Neoplasms | * |
dc.title | Effect of Propofol and Desflurane on Immune Cell Populations in Breast Cancer Patients: A Randomized Trial | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 30 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1503 | * |
dc.relation.lastpage | 1508 | * |
dc.relation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | * |
dc.identifier.doi | 10.3346/jkms.2015.30.10.1503 | * |
dc.identifier.wosid | WOS:000364209600019 | * |
dc.identifier.scopusid | 2-s2.0-84945971842 | * |
dc.author.google | Woo, Jae Hee | * |
dc.author.google | Baik, Hee Jung | * |
dc.author.google | Kim, Chi Hyo | * |
dc.author.google | Chung, Rack Kyung | * |
dc.author.google | Kim, Dong Yeon | * |
dc.author.google | Lee, Guie Yong | * |
dc.author.google | Chun, Eun Hee | * |
dc.contributor.scopusid | 이귀용(15925249600) | * |
dc.contributor.scopusid | 김치효(36059166000) | * |
dc.contributor.scopusid | 정락경(15925032500) | * |
dc.contributor.scopusid | 김동연(55511080500) | * |
dc.contributor.scopusid | 백희정(7101961242) | * |
dc.contributor.scopusid | 우재희(39162370700) | * |
dc.date.modifydate | 20240301081003 | * |