Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상혁 | * |
dc.contributor.author | 김재상 | * |
dc.contributor.author | 정연주 | * |
dc.date.accessioned | 2016-08-27T04:08:19Z | - |
dc.date.available | 2016-08-27T04:08:19Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1949-2553 | * |
dc.identifier.other | OAK-15806 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217708 | - |
dc.description.abstract | SLC22A18, solute carrier family 22, member 18, has been proposed to function as a tumor suppressor based on its chromosomal location at 11p15.5, mutations and aberrant splicing in several types of cancer and down-regulation in glioblastoma. In this study, we sought to demonstrate the significance of SLC22A18 as a tumor suppressor in colorectal cancer (CRC) and provide mechanistic bases for its function. We first showed that the expression of SLC22A18 is significantly down-regulated in tumor tissues using matched normal-tumor samples from CRC patients. This finding was also supported by publically accessible data from The Cancer Genome Atlas (TCGA). Functionally, SLC22A18 inhibits colony formation and induces of G2/M arrest consistent with being a tumor suppressor. Interestingly, suppression of KRAS by RNA interference promotes SLC22A18 expression, and expression of SLC22A18 in turn inhibits KRAS(G12D)-mediated anchorage independent growth of NIH3T3 cells indicating a mutual negative interaction. Finally, we evaluated diagnostic and prognostic values of SLC22A18 using clinical and gene expression data from TCGA which revealed a significantly worse long-term prognosis for patients with low level SLC22A18 expression. In sum, we established SLC22A18 as a tumor suppressor in colon epithelial cells and propose that SLC22A18 is potentially a marker of diagnostic and prognostic values. | * |
dc.language | English | * |
dc.publisher | IMPACT JOURNALS LLC | * |
dc.subject | SLC22A18 | * |
dc.subject | tumor suppressor | * |
dc.subject | colorectal cancer | * |
dc.subject | G2/M arrest | * |
dc.subject | KRAS | * |
dc.title | Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer | * |
dc.type | Article | * |
dc.relation.issue | 28 | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 25368 | * |
dc.relation.lastpage | 25380 | * |
dc.relation.journaltitle | ONCOTARGET | * |
dc.identifier.wosid | WOS:000363160100066 | * |
dc.identifier.scopusid | 2-s2.0-84944474515 | * |
dc.author.google | Jung, Yeonjoo | * |
dc.author.google | Jun, Yukyung | * |
dc.author.google | Lee, Hee-Young | * |
dc.author.google | Kim, Suyeon | * |
dc.author.google | Jung, Yeonhwa | * |
dc.author.google | Keum, Juhee | * |
dc.author.google | Lee, Yeo Song | * |
dc.author.google | Cho, Yong Beom | * |
dc.author.google | Lee, Sanghyuk | * |
dc.author.google | Kim, Jaesang | * |
dc.contributor.scopusid | 이상혁(57212112170) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.contributor.scopusid | 정연주(8777976600) | * |
dc.date.modifydate | 20240429120041 | * |