Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 김한수 | * |
dc.contributor.author | 정성철 | * |
dc.contributor.author | 조인호 | * |
dc.contributor.author | 박주원 | * |
dc.date.accessioned | 2016-08-27T04:08:12Z | - |
dc.date.available | 2016-08-27T04:08:12Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0301-4681 | * |
dc.identifier.issn | 1432-0436 | * |
dc.identifier.other | OAK-15688 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217637 | - |
dc.description.abstract | Tonsil-derived (T-) mesenchymal stem cells (MSCs) display mutilineage differentiation potential and self-renewal capacity and have potential as a banking source. Diabetes mellitus is a prevalent disease in modern society, and the transplantation of pancreatic progenitor cells or various stem cell-derived insulin-secreting cells has been suggested as a novel therapy for diabetes. The potential of T-MSCs to trans-differentiate into pancreatic progenitor cells or insulin-secreting cells has not yet been investigated. We examined the potential of human T-MSCs to trans-differentiate into pancreatic islet cells using two different methods based on beta-mercaptoethanol and insulin-transferin-selenium, respectively. First, we compared the efficacy of the two methods for inducing differentiation into insulin-producing cells. We demonstrated that the insulin-transferin-selenium method is more efficient for inducing differentiation into insulin-secreting cells regardless of the source of the MSCs. Second, we compared the differentiation potential of two different MSC types: T-MSCs and adipose-derived MSCs (A-MSCs). T-MSCs had a differentiation capacity similar to that of A-MSCs and were capable of secreting insulin in response to glucose concentration. Islet-like clusters differentiated from T-MSCs had lower synaptotagmin-3, -5, -7, and -8 levels, and consequently lower secreted insulin levels than cells differentiated from A-MSCs. These results imply that T-MSCs can differentiate into functional pancreatic islet-like cells and could provide a novel, alternative cell therapy for diabetes mellitus. (C) 2015 International Society of Differentiation. Published by Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCI LTD | * |
dc.subject | Insulin | * |
dc.subject | Diabetes | * |
dc.subject | Mesenchymal stem cell | * |
dc.subject | Tonsil | * |
dc.subject | Adipose tissue | * |
dc.title | Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells | * |
dc.type | Article | * |
dc.relation.issue | 42007 | * |
dc.relation.volume | 90 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 27 | * |
dc.relation.lastpage | 39 | * |
dc.relation.journaltitle | DIFFERENTIATION | * |
dc.identifier.doi | 10.1016/j.diff.2015.08.001 | * |
dc.identifier.wosid | WOS:000365802600003 | * |
dc.identifier.scopusid | 2-s2.0-84949531463 | * |
dc.author.google | Kim, So-Yeon | * |
dc.author.google | Kim, Ye-Ryung | * |
dc.author.google | Park, Woo-Jae | * |
dc.author.google | Kim, Han Su | * |
dc.author.google | Jung, Sung-Chul | * |
dc.author.google | Woo, So-Youn | * |
dc.author.google | Jo, Inho | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.author.google | Park, Joo-Won | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 김한수(56509934900) | * |
dc.contributor.scopusid | 정성철(57008539100) | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.contributor.scopusid | 박주원(8656832200) | * |
dc.date.modifydate | 20240422114059 | * |